Clinda-Derm Side Effects
Generic Name: clindamycin topical
Please note - some side effects for Clinda-Derm may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Clinda-Derm Side Effects - for the Professional
Clinda-Derm
Skin dryness is the most common adverse reaction seen with the solution.
Clindamycin has been associated with severe colitis which may end fatally.
Cases of diarrhea, bloody diarrhea and colitis (including pseudomembranous colitis) have been reported as adverse reactions in patients treated with topical formulations of clindamycin.
Other effects which have been reported in association with the use of topical formulations of clindamycin include:
| Abdominal pain | Irritation |
| Contact dermatitis | Oily Skin |
| Gastrointestinal disturbances | Sensitization |
| Gram-negative folliculitis | Stinging of the eye |
Side Effects by Body System - for Healthcare Professionals
Gastrointestinal
Gastrointestinal side effects have included diarrhea in patients treated with topical clindamycin (less than 0.1% incidence), although in most cases it resolved despite continued therapy. Bloody diarrhea and colitis (including pseudomembranous colitis) have been reported rarely with topical clindamycin. In general, these cases involved extemporaneously prepared solutions of clindamycin hydrochloride. Rarely, heartburn, nausea, vomiting, constipation, and abdominal pain have been reported during vaginal use of clindamycin cream. Gastrointestinal disturbances have also been reported with the use of topical clindamycin.
Clindamycin has not been shown to have significant effects on colon flora. In one study, Clostridium difficile was detected in the stool of 4 of 19 patients receiving topical clindamycin for eight weeks. No Clostridium difficile was detected in the stool of patients receiving placebo. However, the difference was not statistically significant. Diarrhea was not reported in any patient.
Local
Local side effects have been frequently reported with the use of topical clindamycin. These have included transient drying, followed by erythema, burning, peeling, and itching. Contact dermatitis has been reported infrequently. Oiliness or oily skin has also been reported.
The foam, gel, and lotion formulations are less drying than the solution formulation, which contains alcohol.
Genitourinary
Genitourinary side effects have included vulvar irritation during use of vaginal clindamycin cream. Yeast overgrowth resulting in the development of fungal vaginitis has been reported. Symptomatic vaginal candida infection has also been reported in approximately 10% of women treated with intravaginal clindamycin.
Nervous system
Nervous system side effects have been reported rarely. Headache, dizziness, and vertigo have been reported with the use of clindamycin vaginal cream.
Other
Other side effects have included one case of ringing in the ear and partial hearing loss believed to be caused by clindamycin.
A 14-year-old boy developed reproducible ringing in his right ear and hearing loss while using topical clindamycin and after discontinuing use. He underwent a complete physical exam and labs which failed to find a cause for his symptoms. The patient was restarted on benzoyl peroxide/clindamycin topical and the ringing in his ear increased. He was told to stop all medications and was started on methylprednisolone. The tinnitus decreased in 1 to 2 days with no improvement in the hearing deficit. After the third time he was restarted on benzoyl peroxide/clindamycin gel, the tinnitus returned at an increased level together with right-sided headaches within 1 to 2 days. The patient again stopped using the benzoyl peroxide and clindamycin gel and the tinnitus returned to a low level over 1 to 2 days. It is believed that the clindamycin component played a part in this patient's tinnitus and hearing loss.
TopMore Clinda-Derm resources
- Clinda-Derm Prescribing Information (FDA)
- Clinda-Derm Topical Advanced Consumer (Micromedex) - Includes Dosage Information
- Clindamycin Topical Prescribing Information (FDA)
- Cleocin T Gel MedFacts Consumer Leaflet (Wolters Kluwer)
- Cleocin Vaginal Advanced Consumer (Micromedex) - Includes Dosage Information
- ClindaMax Cream MedFacts Consumer Leaflet (Wolters Kluwer)
- Clindacin P Prescribing Information (FDA)
- Clindagel Prescribing Information (FDA)
- Clindamax Prescribing Information (FDA)
- Clindesse Consumer Overview
- Clindesse Prescribing Information (FDA)
- Clindesse Cream MedFacts Consumer Leaflet (Wolters Kluwer)
- Evoclin Prescribing Information (FDA)
- Evoclin Consumer Overview
- Evoclin Foam MedFacts Consumer Leaflet (Wolters Kluwer)
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