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Cipro HC Side Effects

Generic Name: ciprofloxacin / hydrocortisone otic

Note: This page contains information about the side effects of ciprofloxacin / hydrocortisone otic. Some of the dosage forms included on this document may not apply to the brand name Cipro HC.

For the Consumer

Applies to ciprofloxacin / hydrocortisone otic: otic suspension

In addition to its needed effects, some unwanted effects may be caused by ciprofloxacin / hydrocortisone otic. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking ciprofloxacin / hydrocortisone otic:

Incidence not known:
  • Blistering, crusting, irritation, itching, or reddening of the skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • cracked, dry, or scaly skin
  • hives or welts
  • itching
  • redness of the skin
  • skin rash
  • swelling

Severity: Minor

Some of the side effects that can occur with ciprofloxacin / hydrocortisone otic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Headache
Incidence not known:
  • Cough
  • hair loss or thinning of hair
  • headache, severe and throbbing

For Healthcare Professionals

Applies to ciprofloxacin / hydrocortisone otic: otic suspension

Nervous system

Nervous system side effects have included headache (1.2%) and rarely, migraine, hypesthesia, and paresthesia.[Ref]


Dermatologic side effects have included pruritus (0.4%) and rarely, urticaria, alopecia, rash, and fungal dermatitis.[Ref]


Respiratory side effects have rarely included cough.[Ref]


1. "Product Information. Cipro HC Otic (ciprofloxacin-hydrocortisone otic)." Bayer, West Haven, CT.

Not all side effects for Cipro HC may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

More about Cipro HC (ciprofloxacin / hydrocortisone otic)

Consumer resources

Professional resources

Other formulations

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.