Chlorpheniramine / phenylephrine / pyrilamine Side Effects

Not all side effects for chlorpheniramine / phenylephrine / pyrilamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to chlorpheniramine / phenylephrine / pyrilamine: suspension, tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur while taking chlorpheniramine / phenylephrine / pyrilamine:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; confusion; difficulty urinating or inability to urinate; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; mood or mental changes; persistent trouble sleeping; restlessness; seizures; severe dizziness, drowsiness, lightheadedness, or headache; tremor.

For Healthcare Professionals

Applies to chlorpheniramine / phenylephrine / pyrilamine: oral liquid, oral suspension, oral suspension extended release, oral tablet, oral tablet extended release

Nervous system

Nervous system side effects including drowsiness and sedation have been reported.[Ref]

Gastrointestinal

Gastrointestinal side effects including dryness of the mucous membranes have been reported.[Ref]

References

1. "Product Information. Poly Hist PD (chlorpheniramine / phenylephrine / pyrilamine)." Poly Pharmaceuticals Inc, Quitman, MS.

2. "PDR Generics. 4th ed." Montvale, NJ: Medical Economics (1998):

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