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CellCept Side Effects

Generic Name: mycophenolate mofetil

Note: This page contains information about the side effects of mycophenolate mofetil. Some of the dosage forms included on this document may not apply to the brand name CellCept.

Not all side effects for CellCept may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to mycophenolate mofetil: oral capsule, oral powder for suspension, oral tablet

In addition to its needed effects, some unwanted effects may be caused by mycophenolate mofetil (the active ingredient contained in CellCept). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking mycophenolate mofetil:

More common
  • Abdominal or stomach cramps or pain
  • black, tarry stools
  • bladder pain
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • bloody or cloudy urine
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • confusion
  • convulsions
  • cough or hoarseness
  • decreased urine
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fainting
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fever or chills
  • flushed, dry skin
  • frequent urge to urinate
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • irregular heartbeats
  • irregular pulse
  • irritability
  • lightheadedness
  • loss of appetite
  • lower back or side pain
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pain or cramps
  • muscle spasms (tetany) or twitching
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • rapid weight gain
  • rapid, shallow breathing
  • seizures
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach pain and bloating
  • sweating
  • swollen glands
  • tightness in the chest
  • tingling of the hands or feet
  • trembling
  • tremor
  • troubled breathing with exertion
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • weakness or heaviness of the legs
Incidence not known
  • Back pain
  • constipation
  • coughing or spitting up blood
  • darkened urine
  • general feeling of illness
  • indigestion
  • night sweats
  • pain
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • severe headache
  • sudden high fever or low-grade fever for months
  • tenderness
  • watery or bloody diarrhea
  • yellow eyes or skin

Some of the side effects that can occur with mycophenolate mofetil may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Acid or sour stomach
  • belching
  • fear
  • heartburn
  • lack or loss of strength
  • rash
  • trouble sleeping
  • weight loss

For Healthcare Professionals

Applies to mycophenolate mofetil: intravenous powder for injection, oral capsule, oral powder for reconstitution, oral tablet


Very common (10% or more): Diarrhea (36%), nausea (20%), vomiting (13%), abdominal pain
Common (1% to 10%): GI infection, gastroenteritis
Rare (less than 0.1%): Gingival hyperplasia, colitis including cytomegalovirus colitis, pancreatitis intestinal villous atrophy
Frequency not reported: Ischemic colitis[Ref]


Very common (10% or more): Leukopenia (11% to 35%), anemia (35%)
Common (1% to 10%): Blood creatinine increased, blood lactate dehydrogenase increased, blood urea increased, blood alkaline phosphatase increased, thrombocytopenia, neutropenia
Very rare (less than 0.01%): Deep venous thrombosis
Postmarketing reports: Pure red cell aplasia (PRCA), abnormal neutrophil morphology, including the acquired Pelger-Huet anomaly[Ref]


Very common (10% or more): Sepsis (primarily cytomegalovirus viremia) (20%), gastrointestinal candidiasis, urinary tract infection, herpes simplex, herpes zoster
Common (1% to 10%): Pneumonia, influenza, respiratory tract infection, respiratory moniliasis, gastrointestinal infection, candidiasis, gastroenteritis, infection, bronchitis, pharyngitis, sinusitis, fungal skin infection, skin candida, vaginal candidiasis
Postmarketing reports: Hypogammaglobulinemia Serious life-threatening infections including meningitis, endocarditis, tuberculosis, atypical mycobacterial infection[Ref]


Common (1% to 10%): Lymphoma, lymphoproliferative disease, non-melanoma skin carcinoma[Ref]


Very common (10% or more): Hematuria (13%), kidney tubular necrosis (up to 10%)
Common (1% to 10%): Renal impairment
Frequency not reported: BK virus-associated nephropathy[Ref]


Very common (10% or more): Edema (12% to 28%), hyperphosphatemia (13%), hypokalemia (10%), hyperglycemia (10%)
Common (1% to 10%): Weight loss, hyperkalemia[Ref]


Very common (10% or more): Respiratory tract infection (23%), dyspnea (16%), increased cough (16%)
Common (1% to 10%): Pneumonia, respiratory moniliasis, bronchitis, pharyngitis, sinusitis, rhinitis, pleural effusion[Ref]


Common (1% to 10%): Fungal skin infection, skin hypertrophy, rash, acne, alopecia
Very rare (less than 0.01%): Dyshidrotic eczema, papulosquamous psoriatic-like skin eruption[Ref]


Common (1% to 10%): Arthralgia
Very rare (less than 0.01%): Myopathy[Ref]


Common (1% to 10%): Edema, pyrexia, chills, pain, malaise, asthenia
Frequency not reported: Congenital malformations, increased incidence of first trimester pregnancy loss[Ref]


Common (1% to 10%): Hepatitis, jaundice, hyperbilirubinemia, hepatic enzyme increased
Very rare (less than 0.01%): Sodium-induced hepatotoxicity[Ref]


Common (1% to 10%): Tachycardia, hypotension, hypertension, vasodilatation
Postmarketing reports: Endocarditis[Ref]


Common (1% to 10%): Urinary tract infection (up to 45%), vaginal candidiasis[Ref]


Postmarketing reports: Angioneurotic edema, anaphylactic reaction[Ref]


1. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL:" ([2006]):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories, Nutley, NJ.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.