Cefmetazole Side Effects
Applies to cefmetazole: injectable powder for injection, intravenous solution
Cefmetazole has been generally well tolerated. In large studies only 2% to 4% of patients reported side effects.[Ref]
Gastrointestinal side effects have included nausea, vomiting, diarrhea, and abdominal pain which were reported in up to 4% of patients.[Ref]
Rare cases of pseudomembranous colitis have been reported.[Ref]
Rare cases of cholestatic jaundice have been reported.
Mild increases in liver function tests may be important in patients with liver disease[Ref]
Hepatic side effects have included rare reports of mild increases in liver function tests.[Ref]
Rare cases of anaphylaxis, hypersensitivity hepatitis, and Stevens-Johnson syndrome have been reported.
A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.[Ref]
Hypersensitivity side effects have included rare reports of a rash (less than 1% of patients).[Ref]
Although mild, insignificant hypoprothrombinemia has been reported. However, no clinically significant hemorrhage or increased bleeding times have been documented.[Ref]
Hematologic side effects have included very rare reports of thrombocytopenia, leukopenia, agranulocytosis, anemia, and eosinophilia.[Ref]
Cardiovascular side effects have included informal reports of hypotension and shock, but the type of infection and clinical conditions of the patients made implication of cefmetazole difficult.[Ref]
Other side effects have included a possible overestimation of urine glucose by the copper reduction method of urine dipstick analysis (Clinitest).[Ref]
The use of glucose oxidase methods (e.g.,Testape, Keto-Diastix, and Chemstrip) to measure urine glucose is recommended during therapy.[Ref]
Renal side effects have included reports of new or worsened renal insufficiency. These were difficult to interpret due to underlying diseases and concomitant therapy.[Ref]
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2. Saito A "Cefmetazole postmarketing surveillance in Japan." J Antimicrob Chemother 23 (1989): 131-9
3. Welage LS, Borin M, Wilton J, Hejmanowski LG, Wels PB, Schentag JJ "Comparative evaluation of the pharmacokinetics of N-methylthiotetrazole following administration of cefoperazone, cefotetan, and cefmetazole." Antimicrob Agents Chemother 34 (1990): 2369-74
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5. Shimada J, Hayashi Y, Nakamura K "Cefmetazole: clinical evaluation of efficacy and safety in Japan." Drugs Exp Clin Res 11 (1985): 181-94
6. Yangco B, Kenyon V, Halkias K, Toney JF, Chmel H "Comparative evaluation of safety and efficacy of cefmetazole and cefoxitin in lower respiratory tract infections." J Antimicrob Chemother 23 (1989): 39-46
7. Romano A, Mayorga C, Torres MJ, Artesani MC, Suau R, Sanchez F, Perez E, Venuti A, Blanca M "Immediate allergic reactions to cephalosporins: Cross-reactivity and selective responses." J Allerg Clin Immunol 106 (2000): 1177-83
8. Filipe P, Almeida RSLS, Rodrigo FG "Occupational allergic contact dermatitis from cephalosporins." Contact Dermatitis 34 (1996): 226
9. Ohishi M, Oobu K, Miyanoshita Y, Yamaguchi K "Acute gingival necrosis caused by drug-induced agranulocytosis." Oral Surg Oral Med Oral Pathol 66 (1988): 194-6
10. Breen GA, Stpeter WL "Hypoprothrombinemia associated with cefmetazole." Ann Pharmacother 31 (1997): 180-4
11. Stanfield J, DiPiro J "Interference of cefmetazole sodium and cefotetan disodium with urine-glucose testing systems." Am J Hosp Pharm 45 (1988): 625-6
Not all side effects for cefmetazole may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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