Cefmetazole Side Effects

Not all side effects for cefmetazole may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Applies to cefmetazole: injectable powder for injection, intravenous solution

General

Cefmetazole has been generally well tolerated. In large studies only 2% to 4% of patients reported side effects.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, diarrhea, and abdominal pain which were reported in up to 4% of patients.

Rare cases of pseudomembranous colitis have been reported.

Hepatic

Rare cases of cholestatic jaundice have been reported.

Mild increases in liver function tests may be important in patients with liver disease

Hepatic side effects have included rare reports of mild increases in liver function tests.

Hypersensitivity

Rare cases of anaphylaxis, hypersensitivity hepatitis, and Stevens-Johnson syndrome have been reported.

A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.

Hypersensitivity side effects have included rare reports of a rash (less than 1% of patients).

Hematologic

Although mild, insignificant hypoprothrombinemia has been reported. However, no clinically significant hemorrhage or increased bleeding times have been documented.

Hematologic side effects have included very rare reports of thrombocytopenia, leukopenia, agranulocytosis, anemia, and eosinophilia.

Cardiovascular

Cardiovascular side effects have included informal reports of hypotension and shock, but the type of infection and clinical conditions of the patients made implication of cefmetazole difficult.

Other

Other side effects have included a possible overestimation of urine glucose by the copper reduction method of urine dipstick analysis (Clinitest).

The use of glucose oxidase methods (e.g.,Testape, Keto-Diastix, and Chemstrip) to measure urine glucose is recommended during therapy.

Renal

Renal side effects have included reports of new or worsened renal insufficiency. These were difficult to interpret due to underlying diseases and concomitant therapy.

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