Cefixime Side Effects
Some side effects of cefixime may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to cefixime: oral capsule, oral powder for suspension, oral tablet, oral tablet chewable
Along with its needed effects, cefixime may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking cefixime:More common
- loose or frequent stools
- Abdominal or stomach pain
- black, tarry stools
- bleeding gums
- blistering, peeling, or loosening of the skin
- blood in the urine or stools
- chest pain
- clay-colored stools
- dark urine
- decreased urine output
- difficulty with swallowing
- fast heartbeat
- feeling of discomfort
- general tiredness and weakness
- inflammation of the joints
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- light-colored stools
- loss of appetite
- lower back or side pain
- muscle aches
- muscle twitching
- nausea and vomiting
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- red skin lesions, often with a purple center
- red, irritated eyes
- shortness of breath
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swelling of the face, ankles, or hands
- swollen glands
- swollen lymph glands
- tightness in the chest
- unpleasant breath odor
- unusual bleeding or bruising
- unusual tiredness or weakness
- upper right abdominal or stomach pain
- vomiting of blood
- yellow eyes or skin
- Abdominal or stomach cramps or tenderness
- back, leg, or stomach pains
- cough or hoarseness
- coughing up blood
- diarrhea, watery and severe, which may also be bloody
- difficulty with breathing
- general body swelling
- increased menstrual flow or vaginal bleeding
- increased thirst
- pain paralysis
- prolonged bleeding from cuts
- red or black, tarry stools
- red or dark brown urine
- sudden decrease in the amount of urine
- unpleasant breath odor
- unusual weight loss
Some side effects of cefixime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- Acid or sour stomach
- excess air or gas in the stomach or intestines
- full feeling
- hives or welts
- itching of the vagina or genital area itching or pain of the genital area
- pain during sexual intercourse
- passing gas
- redness of the skin
- stomach discomfort, upset, or pain
- thick, white vaginal discharge with no odor or with a mild odor
- white patches in the mouth or throat or on the tongue
- white patches with diaper rash
For Healthcare Professionals
Applies to cefixime: oral capsule, oral powder for reconstitution, oral tablet, oral tablet chewable
Cefixime is generally well-tolerated.
Gastrointestinal side effects have included diarrhea (16%), nausea (7%), loose or frequent stools (6%), flatulence (4%), abdominal pain (3%), dyspepsia (3%), vomiting, and pseudomembranous colitis.
Pseudomembranous colitis may occur during or after treatment with cefixime.
Hypersensitivity reactions have included urticaria, rash, pruritus, drug fever, angioedema, facial edema, erythema multiforme, Stevens-Johnson syndrome, serum sickness-like reactions, and toxic epidermal necrolysis. Anaphylactic and anaphylactoid reactions, including shock and fatalities, have also been reported.
A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.
Nervous system side effects have included headache, dizziness, somnolence, and seizures. At least one case of encephalopathy has been reported.
Renal side effects have included transient rises in serum BUN and creatinine, and acute renal failure. Cephalosporin class antibiotics have been associated with renal dysfunction and toxic nephropathy.
Interstitial nephritis has been reported rarely in association with other cephalosporins. Fever, azotemia, pyuria, and eosinophiluria are the hallmarks of this disorder.
Hematologic side effects have included transient thrombocytopenia, eosinophilia, leukopenia, neutropenia, and prothrombin time prolongation. Cephalosporin class antibiotics have been associated with aplastic anemia, hemolytic anemia, hemorrhage, positive direct Coombs test, pancytopenia, and agranulocytosis.
Hepatic side effects have included hepatitis, jaundice, and transient increases in SGPT, SGOT, and alkaline phosphatase. Cephalosporin class antibiotics have been associated with hepatic dysfunction including cholestasis.
Metabolic side effects have included hyperbilirubinemia. Cephalosporin class antibiotics have been associated with increases in LDH.
Genitourinary side effects have included genital pruritus, vaginitis, and candidiasis.
Cephalosporin class antibiotics have been associated with superinfection.
More cefixime resources
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