Cefazolin Side Effects
Some side effects of cefazolin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to cefazolin: injection powder for solution, injection solution
Along with its needed effects, cefazolin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking cefazolin:Rare
- Bluish color
- changes in skin color
- swelling of the foot or leg
- Abdominal or stomach cramps or tenderness
- back, leg, or stomach pains
- black, tarry stools
- bleeding gums
- blistering, peeling, or loosening of the skin
- blood in the urine or stools
- bloody or cloudy urine
- chest pain
- clay-colored stools
- cloudy urine
- coughing up blood
- dark urine
- decrease in urine output or decrease in urine-concentrating ability
- decreased frequency or amount of urine
- diarrhea, watery and severe, which may also be bloody
- difficult or painful urination
- difficulty with breathing or swallowing
- excessive muscle tone
- fast heartbeat
- feeling of discomfort
- general body swelling
- general tiredness and weakness
- increased blood pressure
- increased menstrual flow or vaginal bleeding
- increased thirst
- inflammation of the joints
- itching of the vagina or genital area
- joint or muscle pain
- light-colored stools
- loss of appetite
- lower back or side pain
- muscle aches or stiffness
- muscle tension or tightness
- nausea or vomiting
- pain during sexual intercourse
- pain, warmth, or burning in the fingers, toes, and legs
- pale skin
- pinpoint red spots on the skin
- problems with vision or hearing
- prolonged bleeding from cuts
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red irritated eyes
- red or black, tarry stools
- red or dark brown urine
- red skin lesions, often with a purple center
- red, irritated eyes
- skin rash
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stomach cramps
- sudden decrease in the amount of urine
- swelling of the face, fingers, or lower legs
- swollen lymph glands
- swollen or painful glands
- thick, white vaginal discharge with no odor or with a mild odor
- tightness in the chest
- trouble sitting still
- troubled breathing
- unpleasant breath odor
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight loss
- upper right abdominal pain
- vomiting of blood
- weight gain
- yellowing of the eyes or skin
Some side effects of cefazolin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Incidence not known
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- hives or welts
- redness of the skin
- sore mouth or tongue
- weight loss
- white patches in the mouth, tongue, or throat
For Healthcare Professionals
Applies to cefazolin: injectable powder for injection, injectable solution, intravenous solution
Hypersensitivity side effects have included anaphylaxis, eosinophilia, urticaria, itching, drug fever, skin rash, Stevens-Johnson syndrome, and allergic cross-sensitivity. Cephalosporin-class side effects have included allergic reactions, urticaria, serum sickness-like reaction, erythema multiforme, and toxic epidermal necrolysis.
There is a 10% to 20% risk of allergic cross-sensitivity in patients with a history of allergy to penicillins. A 100% risk of cross-sensitivity should be assumed in all patients with a history of anaphylaxis to penicillins or other cephalosporins.
Dermatologic side effects have included pruritus (including genital, vulvar, and anal pruritus), allergic skin rash, Stevens-Johnson syndrome, fixed drug eruptions, pustular skin eruptions, and contact dermatitis. Cephalosporin-class side effects have included urticaria, serum sickness-like reaction, Stevens-Johnson syndrome, erythema multiforme, and toxic epidermal necrolysis.
A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.
Gastrointestinal side effects have included diarrhea, oral candidiasis (oral thrush), mouth ulcers, vomiting, nausea, abdominal/stomach cramps, epigastric pain, heartburn, flatus, anorexia, anal pruritus, Clostridium difficile-associated diarrhea, and pseudomembranous colitis. Cephalosporin-class side effects have included colitis and abdominal pain.
Onset of pseudomembranous colitis symptoms have been reported during or after antibacterial therapy.
Hematologic side effects have included neutropenia, leukopenia, thrombocytopenia, and thrombocythemia. Cephalosporin-class side effects have included aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, pancytopenia, and agranulocytosis.
A 26-year-old hemodialysis patient with a coagulase-positive staphylococcal arteriovenous fistula graft infection was found to have a hematoma and increased thrombin, prothrombin, and partial thromboplastin times after receiving cefazolin 1 gram intravenously followed by 0.5 gram every 8 hours for 12 days. The laboratory changes resolved after cefazolin therapy was stopped, but recurred when cefazolin was reinstituted.
Hematologic side effects may be more likely in patients with renal insufficiency.
There may be an association between renal failure, high cefazolin levels, and neurological symptoms.
Nervous system side effects have included dizziness, fainting, lightheadedness, confusion, tiredness, somnolence, and headache. Seizures have been reported when inappropriately high doses were administered to patients with renal dysfunction (CrCl less than 55 mL/min). Cephalosporin-class side effects have included reversible hyperactivity and hypertonia.
Renal side effects have included increased BUN, increased creatinine levels, and renal failure. Cephalosporin-class side effects have included renal dysfunction, toxic nephropathy, elevated bilirubin, and increased creatinine. Interstitial nephritis (reversible fever, azotemia, pyuria, and eosinophiluria) has been associated with some cephalosporins.
Hepatic side effects have included transient rise in SGOT, SGPT, and alkaline phosphatase, and hepatitis. Cephalosporin-class side effects have included hepatic dysfunction (including cholestasis) and elevated bilirubin.
Local side effects have included phlebitis at the injection site, pain at the injection site after intramuscular administration, and induration.
Genitourinary side effects have included genital pruritus, vulvar pruritus, vaginitis, and genital moniliasis.
Cardiovascular side effects have included hypotension.
Musculoskeletal side effects have included weakness.
Metabolic side effects associated with cephalosporins as a class have included elevated lactate dehydrogenase.
Other side effects associated with cephalosporins as a class have included superinfection, positive direct Coombs' test, and false-positive test for urinary glucose.
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