Cartrol Side Effects

Generic Name: carteolol

Note: This page contains information about the side effects of carteolol. Some of the dosage forms included on this document may not apply to the brand name Cartrol.

Not all side effects for Cartrol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to carteolol: oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking carteolol (the active ingredient contained in Cartrol) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • slow or uneven heartbeats;

  • feeling light-headed, fainting;

  • feeling short of breath, even with mild exertion;

  • swelling of your ankles or feet;

  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • depression; or

  • cold feeling in your hands and feet.

Less serious side effects of carteolol may include:

  • decreased sex drive, impotence, or difficulty having an orgasm;

  • sleep problems (insomnia);

  • tired feeling; or

  • anxiety, nervousness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to carteolol: oral tablet

General

Carteolol (the active ingredient contained in Cartrol) is generally well-tolerated. Side effects are usually mild and transient.[Ref]

Nervous system

Nervous system side effects include headache in up to 1% to 17%, asthenia in 8%, insomnia in 5%, dizziness in 8%, paresthesias in 2%, and vertigo, nervousness, headache or fatigue in 1% of patients.[Ref]

Cardiovascular

Cardiovascular problems include chest pain in 2% and edema in 1% of patients. Carteolol may cause or worsen AV heart block. In the rare cases of new or worsened congestive heart failure that are associated with carteolol (the active ingredient contained in Cartrol) a cause-and-effect relationship is not established.[Ref]

The etiology of "chest pain" was not described in studies and reviews from the medical literature.[Ref]

Gastrointestinal

Gastrointestinal complaints of abdominal or epigastric pain in 1% to 7% and diarrhea or nausea in 2% of patients is reported.[Ref]

Respiratory

Respiratory side effects are rare. Cough, pharyngitis, or sinusitis are reported in 1% to 5% of patients. Dyspnea is reported rarely. Patients with a history of reactive airways disease may be more likely to become short of breath while taking carteolol (the active ingredient contained in Cartrol) as during therapy with any beta-blocker.[Ref]

Musculoskeletal

Musculoskeletal pain is reported in approximately 3% to 13% of patients.[Ref]

Carteolol and pindolol, beta-adrenergic receptor antagonists with intrinsic sympathomimetic activity (ISA), have more commonly been associated with muscle cramps and elevated serum creatine phosphokinase (CK) levels than beta-blockers without ISA.[Ref]

Genitourinary

Genitourinary complaints of impotence are reported in less than 1% of male patients.[Ref]

Psychiatric

Psychiatric side effects including reports of depression have been associated with carteolol (the active ingredient contained in Cartrol) [Ref]

References

1. "Multum Information Services, Inc. Expert Review Panel"

2. Frishman WH, Covey S "Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism." J Clin Pharmacol 30 (1990): 412-21

3. Simon H, Schuppan U "The treatment of angina pectoris with the new beta-receptor blocker carteolol. Results of a controlled trial in comparison with pindolol." Arzneimittelforschung 33 (1983): 318-21

4. Luther RR, Maurath CJ, Klepper MJ, Peckinpaugh RO, Ringham GL "Carteolol treatment of essential hypertension: a long-term study of safety and efficacy." J Int Med Res 14 (1986): 175-84

5. Luther RR, Glassman HN, Jordan DC "A comparison of carteolol and nadolol in the treatment of stable angina pectoris." J Clin Pharmacol 28 (1988): 634-9

6. Velasquez MT, Byrne D, Hoffmann RG "Antihypertensive effect of carteolol in thiazide-treated hypertensive subjects." J Clin Pharmacol 25 (1985): 601-6

7. Luther RR, Glassman HN, Jordan DC, Klepper MJ "Long-term treatment of angina pectoris with carteolol: a new beta-adrenergic receptor blocking agent." J Int Med Res 14 (1986): 167-74

8. Tarkiainen A, Saraste K, Seppala T, Gordin A, Auvinen J "A controlled study of the antihypertensive effect of carteolol, a new beta-adrenergic receptor blocking drug, in combination with hydrochlorothiazide and amiloride." Eur J Clin Pharmacol 19 (1981): 239-44

9. "Carteolol and penbutolol for hypertension." Med Lett Drugs Ther 31 (1989): 70-1

10. Imai Y, Watanabe N, Hashimoto J, Nishiyama A, Sakuma H, Sekino H, Omata K, Abe K "Muscle cramps and elevated serum creatine phosphokinase levels induced by beta-adrenoceptor blockers." Eur J Clin Pharmacol 48 (1995): 29-34

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