Capastat Sulfate Side Effects

Generic name: capreomycin

Note: This document contains side effect information about capreomycin. Some of the dosage forms listed on this page may not apply to the brand name Capastat Sulfate.

Some side effects of Capastat Sulfate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to capreomycin: intramuscular powder for injection

Get emergency medical help if you have any of these signs of an allergic reaction while taking capreomycin (the active ingredient contained in Capastat Sulfate) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using capreomycin and call your doctor at once if you have any of these serious side effects:

• urinating less than usual or not at all;

• changes in your hearing;

• spinning sensation, problems with balance;

• ringing or roaring sound in your ears; or

• low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).

Less serious side effects of capreomycin may include:

• mild skin rash;

• fever, chills, body aches, flu symptoms; or

• pain, swelling, or a hard lump where the injection was given.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

For Healthcare Professionals

Applies to capreomycin: intramuscular powder for injection

Renal

Renal side effects have included dose-related nephrotoxicity, including BUN elevations (greater than 20 mg/dL) (36%), BUN elevations (greater than 30 mg/dL) (10%), depression of PSP excretion, abnormal urine sediment, renal insufficiency, and oliguria. At least one case of toxic nephritis and acute tubular necrosis has been reported.

A patient with tuberculosis and portal cirrhosis experienced toxic nephritis and acute tubular necrosis coincident with capreomycin therapy. The patient was treated with capreomycin therapy (1 g) and aminosalicylic acid daily for 1 month. The patient developed renal insufficiency and oliguria and died. The autopsy showed subsiding acute tubular necrosis.

Nervous system

Nervous system side effects have included ototoxicity and vestibular toxicity including subclinical auditory loss (11%), clinically apparent hearing loss (3%), vertigo, and tinnitus.

Local

Local side effects have included pain, induration, and excessive bleeding at the injection site.

Hematologic

Hematologic side effects have included leukocytosis, leukopenia, and eosinophilia. Thrombocytopenia has also been reported rarely.

Hepatic

Hepatic side effects have included decreased BSP excretion.

Metabolic

Metabolic side effects including hypokalemia, hypocalcemia, hypomagnesemia, and electrolyte disturbances resembling Bartter's syndrome have been reported.

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