Capastat Sulfate Side Effects

Generic Name: capreomycin

Note: This page contains information about the side effects of capreomycin. Some of the dosage forms included on this document may not apply to the brand name Capastat Sulfate.

Not all side effects for Capastat Sulfate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to capreomycin: injection powder for solution

Along with its needed effects, capreomycin (the active ingredient contained in Capastat Sulfate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking capreomycin:

More common
  • Greatly increased or decreased frequency of urination or amount of urine
  • increased thirst
  • loss of appetite
  • nausea
  • vomiting
Less common
  • Any loss of hearing
  • clumsiness or unsteadiness
  • difficulty in breathing
  • dizziness
  • drowsiness
  • fever
  • irregular heartbeat
  • itching
  • muscle cramps or pain
  • pain, redness, hardness, unusual bleeding, or a sore at the place of injection
  • ringing or buzzing or a feeling of fullness in the ears
  • skin rash
  • swelling
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to capreomycin: intramuscular powder for injection

Renal

Renal side effects have included dose-related nephrotoxicity, including BUN elevations (greater than 20 mg/dL) (36%), BUN elevations (greater than 30 mg/dL) (10%), depression of PSP excretion, abnormal urine sediment, renal insufficiency, and oliguria. At least one case of toxic nephritis and acute tubular necrosis has been reported.

A patient with tuberculosis and portal cirrhosis experienced toxic nephritis and acute tubular necrosis coincident with capreomycin therapy. The patient was treated with capreomycin therapy (1 g) and aminosalicylic acid daily for 1 month. The patient developed renal insufficiency and oliguria and died. The autopsy showed subsiding acute tubular necrosis.

Nervous system

Nervous system side effects have included ototoxicity and vestibular toxicity including subclinical auditory loss (11%), clinically apparent hearing loss (3%), vertigo, and tinnitus.

Local

Local side effects have included pain, induration, and excessive bleeding at the injection site.

Hematologic

Hematologic side effects have included leukocytosis, leukopenia, and eosinophilia. Thrombocytopenia has also been reported rarely.

Hepatic

Hepatic side effects have included decreased BSP excretion.

Metabolic

Metabolic side effects including hypokalemia, hypocalcemia, hypomagnesemia, and electrolyte disturbances resembling Bartter's syndrome have been reported.

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