Skip to Content

Candesartan / hydrochlorothiazide Side Effects

Not all side effects for candesartan / hydrochlorothiazide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to candesartan / hydrochlorothiazide: oral tablet

In addition to its needed effects, some unwanted effects may be caused by candesartan / hydrochlorothiazide. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking candesartan / hydrochlorothiazide:

Less common
  • Cough
  • dizziness
  • dryness of the mouth
  • fever
  • increased thirst
  • irregular heartbeat
  • lightheadedness
  • muscle cramps
  • nausea
  • sore throat
  • unusual tiredness
  • vomiting
  • weak pulse
  • weakness
Rare
  • Arm pain
  • chest pain
  • chest tightness
  • fast or irregular heartbeat
  • large, hive like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • shortness of breath

Some of the side effects that can occur with candesartan / hydrochlorothiazide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Back pain
  • diarrhea
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • runny nose
  • sneezing
  • sweating
  • trouble sleeping

For Healthcare Professionals

Applies to candesartan / hydrochlorothiazide: oral tablet

Respiratory

Common (1% to 10%): Upper respiratory tract infection, respiratory infection, bronchitis, pharyngitis, sinusitis, nasopharyngitis, cough

Candesartan:
Frequency not reported: Cough, rhinitis

Hydrochlorothiazide:
Frequency not reported: Pneumonitis, pulmonary edema[Ref]

Metabolic

Common (1% to 10%): Hypokalemia, dyslipidemia
Uncommon (0.1% to 1%): Hyperkalemia

Candesartan:
Very rare (less than 0.01%): Hyponatremia, hyperkalemia

Hydrochlorothiazide:
Frequency not reported: Anorexia, loss of appetite, hyperglycemia, hyperuricemia, hyponatremia, hypokalemia, cholesterol increased, triglycerides increased[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, nausea
Uncommon (0.1% to 1%): Vomiting

Candesartan:
Frequency not reported: Diarrhea

Hydrochlorothiazide:
Frequency not reported: Gastric irritation, diarrhea, constipation
Postmarketing reports: Sialadenitis, cramping[Ref]

Other

Common (1% to 10%): Influenza-like symptoms, inflicted injury
Frequency not reported: Fatigue

Candesartan:
Frequency not reported: Peripheral edema

Hydrochlorothiazide:
Frequency not reported: Fever, weakness, vertigo[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Candesartan:
Postmarketing reports: Somnolence

Hydrochlorothiazide:
Frequency not reported: Lightheadedness, paresthesia[Ref]

Cardiovascular

Common (1% to 10%): Tachycardia
Uncommon (0.1% to 1%): Atrioventricular block

Candesartan:
Postmarketing reports: Palpitations

Hydrochlorothiazide:
Frequency not reported: Vasculitis, postural hypotension, cardiac arrhythmias[Ref]

Musculoskeletal

Common (1% to 10%): Back pain
Postmarketing reports: Myalgia

Candesartan:
Postmarketing reports: Rhabdomyolysis

Hydrochlorothiazide:
Frequency not reported: Muscle spasm[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection

Hydrochlorothiazide:
Frequency not reported: Glycosuria
Postmarketing reports: Impotence[Ref]

Dermatologic

Candesartan:
Very rare (less than 0.01%): Angioedema, urticaria, pruritus, rash

Hydrochlorothiazide:
Frequency not reported: Photosensitivity reactions, rash, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, urticaria, cutaneous vasculitis, toxic epidermal necrolysis
Postmarketing reports: Purpura, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, alopecia[Ref]

Hematologic

Candesartan:
Very rare (less than 0.01%): Leucopenia, neutropenia, agranulocytosis

Hydrochlorothiazide:
Frequency not reported: Leucopenia, neutropenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, bone marrow depression[Ref]

Hepatic

Candesartan:
Very rare (less than 0.01%): Liver enzymes increased, abnormal hepatic function, hepatitis

Hydrochlorothiazide:
Frequency not reported: Intrahepatic cholestatic jaundice, pancreatitis[Ref]

Renal

Candesartan:
Very rare (less than 0.01%): Renal impairment, renal failure

Hydrochlorothiazide:
Frequency not reported: BUN increased, serum creatinine increased, renal dysfunction, interstitial nephritis[Ref]

Psychiatric

Candesartan:
Postmarketing reports: Agitation, anxiety, depression, insomnia, nervousness, sleep disorder, nightmare

Hydrochlorothiazide:
Frequency not reported: Restlessness, sleep disturbances, depression[Ref]

Ocular

Hydrochlorothiazide:
Frequency not reported: Transient blurred vision, acute myopia, acute angle-closure glaucoma, xanthopsia[Ref]

Immunologic

Hydrochlorothiazide:
Frequency not reported: Anaphylactic reactions[Ref]

References

1. "Product Information. Atacand HCT (candesartan-hydrochlorothiazide)" AstraZeneca Pharmaceuticals, Wilmington, DE.

2. Cerner Multum, Inc. "Australian Product Information." O 0

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide