Brintellix Side Effects

Generic Name: vortioxetine

Note: This page contains information about the side effects of vortioxetine. Some of the dosage forms included on this document may not apply to the brand name Brintellix.

Not all side effects for Brintellix may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to vortioxetine: oral tablet

Along with its needed effects, vortioxetine (the active ingredient contained in Brintellix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vortioxetine:

Incidence not known
  • Agitation
  • blood in the stool or urine
  • coma
  • confusion
  • convulsions
  • decreased urine output
  • diarrhea
  • dizziness
  • fast or irregular heartbeat
  • fever
  • headache
  • increased thirst
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • muscle pain or cramps
  • nausea or vomiting
  • nose bleeds
  • overactive reflexes
  • poor coordination
  • red or purple spots on the skin
  • restlessness
  • shivering
  • shortness of breath
  • sweating
  • swelling of the face, ankles, or hands
  • talking or acting with excitement you cannot control
  • trembling or shaking
  • twitching
  • unusual bruising
  • unusual tiredness or weakness
  • vomiting blood

Some side effects of vortioxetine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty having a bowel movement (stool)
  • dry mouth
Less common
  • Bloated or full feeling
  • excess air or gas in the stomach or intestines
  • itching skin
  • passing gas
  • unusual dreams
Incidence not known
  • Acid or sour stomach
  • belching
  • change in taste
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • heartburn
  • indigestion
  • loss of taste
  • redness of the face, neck, arms, and occasionally, upper chest
  • sensation of spinning
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to vortioxetine: oral tablet


Very common (10% or more): Nausea (21 to 32%)
Common (1% to 10%): Diarrhea (7 to 10%), dry mouth (6 to 8%), constipation (3 to 6%), vomiting (3 to 6%), flatulence (1 to 3%)
Frequency not reported: Dyspepsia


Nausea was the most common adverse reaction and appeared to be dose related. Nausea was more common in females than in males and usually occurred in the first week of treatment.

Nervous system

Common (1% to 10%): Dizziness (6 to 9%), abnormal dreams (less than 1 to 3%)
Frequency not reported: Dysgeusia, vertigo


When vortioxetine (the active ingredient contained in Brintellix) is abruptly discontinued some patients experience headache, muscle tension, mood swings, sudden outbursts of anger, dizziness, and runny nose.


Very common (10% or more): Difficulties in sexual desire, sexual performance and sexual satisfaction (16 to 34%). Note: Sexual dysfunction and decreased desire often occur as manifestations of psychiatric disorders, but may also be consequences of pharmacologic treatment.

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