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Brintellix Side Effects

Generic Name: vortioxetine

Note: This page contains information about the side effects of vortioxetine. Some of the dosage forms included on this document may not apply to the brand name Brintellix.

Not all side effects for Brintellix may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to vortioxetine: oral tablet

In addition to its needed effects, some unwanted effects may be caused by vortioxetine (the active ingredient contained in Brintellix). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking vortioxetine:

Incidence not known
  • Agitation
  • blood in the stool or urine
  • coma
  • confusion
  • convulsions
  • decreased urine output
  • diarrhea
  • dizziness
  • fast or irregular heartbeat
  • fever
  • headache
  • increased thirst
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • muscle pain or cramps
  • nausea or vomiting
  • nose bleeds
  • overactive reflexes
  • poor coordination
  • red or purple spots on the skin
  • restlessness
  • shivering
  • shortness of breath
  • sweating
  • swelling of the face, ankles, or hands
  • talking or acting with excitement you cannot control
  • trembling or shaking
  • twitching
  • unusual bruising
  • unusual tiredness or weakness
  • vomiting blood

Some of the side effects that can occur with vortioxetine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Difficulty having a bowel movement (stool)
  • dry mouth
Less common
  • Bloated or full feeling
  • excess air or gas in the stomach or intestines
  • itching skin
  • passing gas
  • unusual dreams
Incidence not known
  • Acid or sour stomach
  • belching
  • blurred vision
  • change in taste
  • dizziness or lightheadedness
  • eye pain
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • heartburn
  • indigestion
  • loss of taste
  • redness of the face, neck, arms, and occasionally, upper chest
  • sensation of spinning
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to vortioxetine: oral tablet

General

The most commonly reported side effects were difficulties in sexual desire, sexual performance, sexual satisfaction, and nausea.[Ref]

Psychiatric

Very common (10% or more): Difficulties in sexual desire, sexual performance, sexual satisfaction (up to 34%)
Common (1% to 10%) Abnormal dreams
Rare(less than 0.1%): Mania, hypomania[Ref]

Hypersensitivity

Frequency not reported: Angioedema[Ref]

Nervous system

Common (1% to 10%): Dizziness
Frequency not reported: Serotonin syndrome, dysgeusia, vertigo[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 32%), diarrhea (up to 10%)
Common (1% to 10%): Dry mouth, constipation, vomiting, flatulence
Frequency not reported: Dyspepsia[Ref]

Other

Frequency not reported: Discontinuation symptoms such as headache, muscle tension, mood swings, sudden outbursts of anger, dizziness, runny nose[Ref]

Dermatologic

Common (1% to 10%): Pruritus[Ref]

Cardiovascular

Frequency not reported: Flushing[Ref]

References

1. "Product Information. Brintellix (vortioxetine)." Takeda Pharmaceuticals America, Lincolnshire, IL.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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