Brintellix Side Effects

Generic Name: vortioxetine

Note: This document contains side effect information about vortioxetine. Some of the dosage forms listed on this page may not apply to the brand name Brintellix.

Some side effects of Brintellix may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to vortioxetine: oral tablet

Along with its needed effects, vortioxetine (the active ingredient contained in Brintellix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vortioxetine:

Incidence not known
  • Agitation
  • blood in the stool or urine
  • coma
  • confusion
  • convulsions
  • decreased urine output
  • diarrhea
  • dizziness
  • fast or irregular heartbeat
  • fever
  • headache
  • increased thirst
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • muscle pain or cramps
  • nausea or vomiting
  • nose bleeds
  • overactive reflexes
  • poor coordination
  • red or purple spots on the skin
  • restlessness
  • shivering
  • shortness of breath
  • sweating
  • swelling of the face, ankles, or hands
  • talking or acting with excitement you cannot control
  • trembling or shaking
  • twitching
  • unusual bruising
  • unusual tiredness or weakness
  • vomiting blood

Some side effects of vortioxetine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty having a bowel movement (stool)
  • dry mouth
Less common
  • Bloated or full feeling
  • excess air or gas in the stomach or intestines
  • itching skin
  • passing gas
  • unusual dreams
Incidence not known
  • Acid or sour stomach
  • belching
  • change in taste
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • heartburn
  • indigestion
  • loss of taste
  • redness of the face, neck, arms, and occasionally, upper chest
  • sensation of spinning
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to vortioxetine: oral tablet

Gastrointestinal

Very common (10% or more): Nausea (21 to 32%)
Common (1% to 10%): Diarrhea (7 to 10%), dry mouth (6 to 8%), constipation (3 to 6%), vomiting (3 to 6%), flatulence (1 to 3%)
Frequency not reported: Dyspepsia

General

Nausea was the most common adverse reaction and appeared to be dose related. Nausea was more common in females than in males and usually occurred in the first week of treatment.

Nervous system

Common (1% to 10%): Dizziness (6 to 9%), abnormal dreams (less than 1 to 3%)
Frequency not reported: Dysgeusia, vertigo

Other

When vortioxetine (the active ingredient contained in Brintellix) is abruptly discontinued some patients experience headache, muscle tension, mood swings, sudden outbursts of anger, dizziness, and runny nose.

Psychiatric

Very common (10% or more): Difficulties in sexual desire, sexual performance and sexual satisfaction (16 to 34%). Note: Sexual dysfunction and decreased desire often occur as manifestations of psychiatric disorders, but may also be consequences of pharmacologic treatment.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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