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Brilinta Side Effects

Generic Name: ticagrelor

Note: This page contains information about the side effects of ticagrelor. Some of the dosage forms included on this document may not apply to the brand name Brilinta.

Not all side effects for Brilinta may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ticagrelor: oral tablet

In addition to its needed effects, some unwanted effects may be caused by ticagrelor (the active ingredient contained in Brilinta). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking ticagrelor:

More common
  • Difficult or labored breathing
  • shortness of breath
  • tightness in the chest
Less common
  • Blurred vision
  • chest pain or discomfort
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast or irregular heartbeat
  • headache
  • lightheadedness, dizziness, or fainting
  • loss of consciousness
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
  • sweating
  • unusual tiredness or weakness
Incidence not known
  • Bleeding gums
  • bruising
  • coughing up blood
  • difficulty with breathing or swallowing
  • headache, sudden and severe
  • increased menstrual flow or vaginal bleeding
  • nausea or vomiting
  • nosebleeds
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • weakness

Some of the side effects that can occur with ticagrelor may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Back pain
  • cough
  • diarrhea
  • Swelling of the breasts or breast soreness in both females and males

For Healthcare Professionals

Applies to ticagrelor: oral tablet


Hematologic side effects have included fatal/life-threatening bleeding such as intracranial; intrapericardial bleed with cardiac tamponade; hypovolemic shock or severe hypotension due to bleeding and requiring pressors or surgery; clinically overt or apparent bleeding associated with a decrease in hemoglobin (Hb) of more than 5 g/dL; transfusion of 4 or more units (whole blood or packed red blood cells (PRBCs)) for bleeding; major bleeding such as significantly disabling (e.g., intraocular with permanent vision loss); clinically overt or apparent bleeding associated with a decrease in Hb of 3 g/dL; transfusion of 2 to 3 units (whole blood or PRBCs) for bleeding; minor bleeding which requires medical intervention to stop or treat bleeding (e.g., epistaxis requiring visit to medical facility for packing); minimal bleeding such as bruising, bleeding gums, oozing from injection sites, not requiring intervention or treatment.[Ref]


Cardiovascular side effects have included atrial fibrillation, hypertension, hypotension, chest pain, and bradycardia.[Ref]


Musculoskeletal side effects have included noncardiac chest pain and back pain.[Ref]

Nervous system

Nervous system side effects have included headache and dizziness.[Ref]


Respiratory side effects have included cough, dyspnea, exertional dyspnea, dyspnea at rest, nocturnal dyspnea, and paroxysmal nocturnal dyspnea.[Ref]


Gastrointestinal side effects have include nausea and diarrhea.[Ref]


General side effects have included fatigue.[Ref]


Endocrine side effects have included gynecomastia.[Ref]


Hypersensitivity side effects have included postmarketing reports of hypersensitivity reactions including angioedema.


1. "Product Information. Brilinta (ticagrelor)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.