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BiDil Side Effects

Generic Name: hydralazine / isosorbide dinitrate

Note: This page contains information about the side effects of hydralazine / isosorbide dinitrate. Some of the dosage forms included on this document may not apply to the brand name BiDil.

Not all side effects for BiDil may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to hydralazine / isosorbide dinitrate: oral tablet

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

This medicine can cause headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use the medicine. Do not stop taking hydralazine and isosorbide dinitrate. Call your doctor before using any headache pain medication.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • numbness or tingling in your hands or feet;

  • joint pain or swelling;

  • fever, chest pain, general ill feeling;

  • fast heart rate;

  • shortness of breath that is worse than usual; or

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

Some side effects may be more likely in older adults.

Common side effects may include:

  • headache; or

  • dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to hydralazine / isosorbide dinitrate: oral tablet

General

The most common side effects were headache, dizziness, asthenia, and nausea.[Ref]

Nervous system

Very common (10% or more): Headache (50%), dizziness (32%)
Common (1% to 10%): Paresthesia
Postmarketing reports: Tinnitus, dysgeusia, hypoesthesia, migraine, syncope[Ref]

Other

Very common (10% or more): Asthenia (14%)
Postmarketing reports: Vertigo, facial pain, chest discomfort, chest pain, peripheral edema[Ref]

Gastrointestinal

Very common (10% or more): Nausea (10%)
Common (1% to 10%): Vomiting
Postmarketing reports: Abdominal discomfort, constipation[Ref]

Cardiovascular

Common (1% to 10%): Hypotension, ventricular tachycardia
Postmarketing reports: Palpitations, flushing[Ref]

Ocular

Common (1% to 10%): Amblyopia
Postmarketing reports: Eyelid edema, vision blurred[Ref]

Respiratory

Common (1% to 10%): Sinusitis
Postmarketing reports: Dyspnea[Ref]

Dermatologic

Postmarketing reports: Erythema, hyperhidrosis, pruritus, face swelling[Ref]

Genitourinary

Postmarketing reports: Chromaturia, erectile dysfunction[Ref]

Musculoskeletal

Postmarketing reports: Pain in extremity, myalgia[Ref]

Renal

Postmarketing reports: Pulmonary renal syndrome[Ref]

References

1. "Product Information. BiDil (hydralazine-isosorbide dinitrate)." NitroMed Inc, Lexington, MA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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