Bicillin C-R Side Effects

Generic Name: benzathine penicillin / procaine penicillin

Note: This page contains information about the side effects of benzathine penicillin / procaine penicillin. Some of the dosage forms included on this document may not apply to the brand name Bicillin C-R.

Not all side effects for Bicillin C-R may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Applies to benzathine penicillin / procaine penicillin: intramuscular suspension

Hypersensitivity

Hypersensitivity side effects associated with parenteral penicillin G have included skin eruptions (maculopapular to exfoliative dermatitis), urticaria, laryngeal edema, fever, eosinophilia, other serum sickness-like reactions (including chills, fever, edema, arthralgia, and prostration), and anaphylaxis (including shock and death). Hypersensitivity reactions including allergic vasculitis, pruritus, fatigue, asthenia, and pain have been temporally associated with parenteral penicillin G benzathine use.

Nervous system

Nervous system side effects associated with parenteral penicillin G have included neuropathy. Headache, tremors, dizziness, somnolence, transverse myelitis, seizures, and coma have been temporally associated with parenteral penicillin G benzathine use.

Gastrointestinal

The onset of pseudomembranous colitis symptoms may occur during or after treatment.

Gastrointestinal side effects associated with parenteral penicillin G have included pseudomembranous colitis. Nausea, vomiting, blood in stool, and intestinal necrosis have been temporally associated with parenteral penicillin G benzathine use.

Psychiatric

Psychiatric side effects temporally associated with parenteral penicillin G benzathine have included nervousness, confusion, anxiety, and euphoria. A syndrome manifested by a variety of central nervous system symptoms such as severe agitation with confusion, visual and auditory hallucinations, and a fear of impending death (Hoigne's syndrome) has been reported following procaine penicillin use, and less commonly, following benzathine penicillin-procaine penicillin use. Other symptoms associated with this syndrome have included psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia, and abnormal taste perception.

Cardiovascular

Cardiovascular side effects temporally associated with parenteral penicillin G benzathine have included cardiac arrest, hypotension, tachycardia, palpitations, pulmonary hypertension, pulmonary embolism, vasodilation, vasovagal reaction, cerebrovascular accident, and syncope.

Renal

Renal side effects associated with parenteral penicillin G have included nephropathy. Elevated BUN, elevated creatinine, and renal failure have been temporally associated with parenteral penicillin G benzathine use.

Hematologic

Hematologic side effects associated with parenteral penicillin G have included hemolytic anemia, leukopenia, and thrombocytopenia. Lymphadenopathy has been temporally associated with parenteral penicillin G benzathine use.

Local

Local side effects temporally associated with parenteral penicillin G benzathine have included injection site reactions, including pain, inflammation, lump, abscess, necrosis, edema, hemorrhage, cellulitis, hypersensitivity, atrophy, ecchymosis, and skin ulcer. Neurovascular reactions including warmth, vasospasm, pallor, mottling, gangrene, numbness of the extremities, cyanosis of the extremities, and neurovascular damage have been temporally associated with parenteral penicillin G benzathine use.

Respiratory

Respiratory side effects temporally associated with parenteral penicillin G benzathine have included hypoxia, apnea, and dyspnea.

Hepatic

Hepatic side effects temporally associated with parenteral penicillin G benzathine have included elevated serum glutamic oxaloacetic transaminase (SGOT).

Musculoskeletal

Musculoskeletal side effects temporally associated with parenteral penicillin G benzathine have included joint disorder, periostitis, myoglobinuria, rhabdomyolysis, and exacerbation of arthritis.

Ocular

Ocular side effects temporally associated with parenteral penicillin G benzathine have included blurred vision and blindness.

Genitourinary

Genitourinary side effects temporally associated with parenteral penicillin G benzathine have included neurogenic bladder, hematuria, proteinuria, impotence, and priapism.

Other

Other side effects temporally associated with parenteral penicillin G benzathine have included aggravation of existing disorder.

Dermatologic

Dermatologic side effects temporally associated with parenteral penicillin G benzathine have included diaphoresis.

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