Bicillin C-R Side Effects

Please note - some side effects for Bicillin C-R may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Bicillin C-R - for the Consumer

Bicillin C-R Suspension

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Bicillin C-R Suspension:

Blurred vision; dizziness; drowsiness; mild diarrhea; nausea; pain, swelling, or redness at the injection site; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur when using Bicillin C-R Suspension:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; bizarre behavior; blood in urine; bloody stools; chest pain; chills; confusion; extreme tiredness; fainting; fast heartbeat; fever; flushing with lightheadedness or fainting; hallucinations; headache; itching; muscle pain; pounding in the chest; rapid breathing; seizures; severe diarrhea; stomach pain/cramps; vaginal irritation or itching; worsening of skin lesions.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

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Bicillin C-R Side Effects - for the Professional

Bicillin C-R

As with other penicillins, untoward reactions of the sensitivity phenomena are likely to occur, particularly in individuals who have previously demonstrated hypersensitivity to penicillins or in those with a history of allergy, asthma, hay fever, or urticaria.

The following have been reported with parenteral penicillin G:

General: Hypersensitivity reactions including the following: skin eruptions (maculopapular to exfoliative dermatitis), urticaria, laryngeal edema, fever, eosinophilia; other serum sickness-like reactions (including chills, fever, edema, arthralgia, and prostration); and anaphylaxis including shock and death. Note: Urticaria, other skin rashes, and serum sickness-like reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur, penicillin G should be discontinued unless, in the opinion of the physician, the condition being treated is life-threatening and amenable only to therapy with penicillin G. Serious anaphylactic reactions require immediate emergency treatment with epinephrine. Oxygen, intravenous steroids, and airway management, including intubation, should also be administered as indicated.

Gastrointestinal: Pseudomembranous colitis. Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment.

Hematologic: Hemolytic anemia, leukopenia, thrombocytopenia.

Neurologic: Neuropathy.

Urogenital: Nephropathy.

The following adverse events have been temporally associated with parenteral administrations of penicillin G benzathine:

Body as a Whole: Hypersensitivity reactions including allergic vasculitis, pruritis, fatigue, asthenia, and pain; aggravation of existing disorder; headache.

Cardiovascular: Cardiac arrest; hypotension; tachycardia; palpitations; pulmonary hypertension; pulmonary embolism; vasodilation; vasovagal reaction; cerebrovascular accident; syncope.

Gastrointestinal: Nausea, vomiting; blood in stool; intestinal necrosis.

Hemic and Lymphatic: Lymphadenopathy.

Injection Site: Injection site reactions including pain, inflammation, lump, abscess, necrosis, edema, hemorrhage, cellulitis, hypersensitivity, atrophy, ecchymosis, and skin ulcer. Neurovascular reactions including warmth, vasospasm, pallor, mottling, gangrene, numbness of the extremities, cyanosis of the extremities, and neurovascular damage.

Metabolic: Elevated BUN, creatinine, and SGOT.

Musculoskeletal: Joint disorder, periostitis; exacerbation of arthritis; myoglobinuria; rhabdomyolysis.

Nervous System: Nervousness; tremors; dizziness; somnolence; confusion; anxiety; euphoria; transverse myelitis; seizures; coma. A syndrome manifested by a variety of CNS symptoms such as severe agitation with confusion, visual and auditory hallucinations, and a fear of impending death (Hoigne’s syndrome), has been reported after administration of penicillin G procaine and, less commonly, after injection of the combination of penicillin G benzathine and penicillin G procaine. Other symptoms associated with this syndrome, such as psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia, and/or abnormal perception in taste, also may occur.

Respiratory: Hypoxia; apnea; dyspnea.

Skin: Diaphoresis.

Special Senses: Blurred vision; blindness.

Urogenital: Neurogenic bladder; hematuria; proteinuria; renal failure; impotence; priapism.

OVERDOSAGE

Penicillin in overdosage has the potential to cause neuromuscular hyperirritability or convulsive seizures.

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Side Effects by Body System - for Healthcare Professionals

Hypersensitivity

Hypersensitivity side effects associated with parenteral penicillin G have included skin eruptions (maculopapular to exfoliative dermatitis), urticaria, laryngeal edema, fever, eosinophilia, other serum sickness-like reactions (including chills, fever, edema, arthralgia, and prostration), and anaphylaxis (including shock and death). Hypersensitivity reactions including allergic vasculitis, pruritus, fatigue, asthenia, and pain have been temporally associated with parenteral penicillin G benzathine use.

Nervous system

Nervous system side effects associated with parenteral penicillin G have included neuropathy. Headache, tremors, dizziness, somnolence, transverse myelitis, seizures, and coma have been temporally associated with parenteral penicillin G benzathine use.

Gastrointestinal

The onset of pseudomembranous colitis symptoms may occur during or after treatment.

Gastrointestinal side effects associated with parenteral penicillin G have included pseudomembranous colitis. Nausea, vomiting, blood in stool, and intestinal necrosis have been temporally associated with parenteral penicillin G benzathine use.

Psychiatric

Psychiatric side effects temporally associated with parenteral penicillin G benzathine have included nervousness, confusion, anxiety, and euphoria. A syndrome manifested by a variety of central nervous system symptoms such as severe agitation with confusion, visual and auditory hallucinations, and a fear of impending death (Hoigne's syndrome) has been reported following procaine penicillin use, and less commonly, following benzathine penicillin-procaine penicillin use. Other symptoms associated with this syndrome have included psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia, and abnormal taste perception.

Cardiovascular

Cardiovascular side effects temporally associated with parenteral penicillin G benzathine have included cardiac arrest, hypotension, tachycardia, palpitations, pulmonary hypertension, pulmonary embolism, vasodilation, vasovagal reaction, cerebrovascular accident, and syncope.

Renal

Renal side effects associated with parenteral penicillin G have included nephropathy. Elevated BUN, elevated creatinine, and renal failure have been temporally associated with parenteral penicillin G benzathine use.

Hematologic

Hematologic side effects associated with parenteral penicillin G have included hemolytic anemia, leukopenia, and thrombocytopenia. Lymphadenopathy has been temporally associated with parenteral penicillin G benzathine use.

Local

Local side effects temporally associated with parenteral penicillin G benzathine have included injection site reactions, including pain, inflammation, lump, abscess, necrosis, edema, hemorrhage, cellulitis, hypersensitivity, atrophy, ecchymosis, and skin ulcer. Neurovascular reactions including warmth, vasospasm, pallor, mottling, gangrene, numbness of the extremities, cyanosis of the extremities, and neurovascular damage have been temporally associated with parenteral penicillin G benzathine use.

Respiratory

Respiratory side effects temporally associated with parenteral penicillin G benzathine have included hypoxia, apnea, and dyspnea.

Hepatic

Hepatic side effects temporally associated with parenteral penicillin G benzathine have included elevated serum glutamic oxaloacetic transaminase (SGOT).

Musculoskeletal

Musculoskeletal side effects temporally associated with parenteral penicillin G benzathine have included joint disorder, periostitis, myoglobinuria, rhabdomyolysis, and exacerbation of arthritis.

Ocular

Ocular side effects temporally associated with parenteral penicillin G benzathine have included blurred vision and blindness.

Genitourinary

Genitourinary side effects temporally associated with parenteral penicillin G benzathine have included neurogenic bladder, hematuria, proteinuria, impotence, and priapism.

Other

Other side effects temporally associated with parenteral penicillin G benzathine have included aggravation of existing disorder.

Dermatologic

Dermatologic side effects temporally associated with parenteral penicillin G benzathine have included diaphoresis.

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