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Betagan Side Effects

Generic Name: levobunolol ophthalmic

Note: This page contains information about the side effects of levobunolol ophthalmic. Some of the dosage forms included on this document may not apply to the brand name Betagan.

Not all side effects for Betagan may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to levobunolol ophthalmic: ophthalmic solution

In addition to its needed effects, some unwanted effects may be caused by levobunolol ophthalmic (the active ingredient contained in Betagan). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking levobunolol ophthalmic:

More common
  • Burning or stinging in eye
  • drainage from the eye
  • redness, swelling, and/or itching of eye and eyelid
Less common
  • Blurred vision
  • chest pain or discomfort
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • shortness of breath
  • slow or irregular heartbeat
  • sweating
  • unusual tiredness or weakness
  • Eye pain
  • headache
  • hives or welts
  • itching skin
  • redness of skin
  • shakiness and unsteady walk
  • skin rash
  • tearing
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual drowsiness, dullness, or feeling of sluggishness
Incidence not determined
  • Blistering, peeling, loosening of skin
  • blue lips, fingernails, or skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chills
  • cough
  • decreased urine output
  • diarrhea
  • difficult or labored breathing
  • difficulty in chewing, swallowing, or talking
  • dilated neck veins
  • disturbed color perception
  • double vision
  • drooping eyelids
  • extreme fatigue
  • fast, pounding, or racing heartbeat or pulse
  • fever
  • halos around lights
  • hoarseness
  • inability to speak
  • irregular, fast or slow, or shallow breathing
  • irritation
  • joint pain, stiffness, or swelling
  • muscle pain
  • muscle weakness
  • night blindness
  • no blood pressure or pulse
  • noisy breathing
  • overbright appearance of lights
  • red skin lesions, often with a purple center
  • seeing double
  • seizures
  • severe numbness, especially on one side of the face or body
  • severe or sudden headache
  • severe tiredness
  • slurred speech
  • sore throat
  • sores, ulcers, or white spots in mouth or on lips
  • stopping of heart
  • swelling of eyelids, face, lips, hands, fingers, feet, or lower legs
  • temporary blindness
  • tightness in chest
  • troubled breathing
  • tunnel vision
  • unconsciousness
  • weakness in arm and/or leg on one side of the body, sudden and severe
  • weight gain
  • wheezing

Some of the side effects that can occur with levobunolol ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not determined
  • Decreased interest in sexual intercourse
  • discouragement
  • feeling sad or empty
  • inability to have or keep an erection
  • irritability
  • lack of appetite
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • loss of interest or pleasure
  • nausea
  • stuffy nose
  • tiredness
  • trouble concentrating
  • trouble sleeping

For Healthcare Professionals

Applies to levobunolol ophthalmic: ophthalmic solution


The most commonly reported side effects were ocular burning/stinging, blepharoconjunctivitis, eye irritation, and eye pain.[Ref]


Very common (10% or more): Eye irritation, eye pain
Common (1% to 10%): Blepharitis, conjunctivitis
Rare (less than 0.1%): Iridocyclitis
Frequency not reported: Conjunctival/ocular hyperemia, allergic conjunctivitis, decreased corneal reflex, keratitis, blurred vision, punctate keratitis, eye/eyelids pruritus, eye/eyelid edema, eye discharge, increased lacrimation, dry eye, choroidal detachment following filtration surgery, corneal erosion, diplopia, ptosis, corneal calcification, decreased corneal sensitivity, blepharoptosis[Ref]


Frequency not reported: Asthma, dyspnea, throat irritation, nasal discomfort, bronchospasm (predominantly in patients with pre-existing bronchospastic disease), cough, respiratory failure, nasal congestion[Ref]


Frequency not reported: Raynaud's phenomenon, syncope, bradycardia, atrioventricular block, palpitations, hypotension, arrhythmia, cardiac arrest, cardiac failure, chest pain, congestive heart failure, cold hands and feet[Ref]


Frequency not reported: Anaphylactic reaction, systemic allergic reactions including angioedema[Ref]

Nervous system

Rare (less than 0.1%): Transient ataxia
Frequency not reported: Confusion, dizziness, somnolence, lethargy, headache, memory loss, cerebral ischemia, cerebrovascular accident, increases in signs and symptoms of myasthenia gravis, paresthesia, dysgeusia[Ref]


Frequency not reported: Nausea, abdominal pain, diarrhea, dry mouth, dyspepsia, vomiting[Ref]


Frequency not reported: Decreased libido, sexual dysfunction, impotence[Ref]


Frequency not reported: Myalgia[Ref]


Frequency not reported: Depression, insomnia, nightmares[Ref]


Frequency not reported: Edema, fatigue, asthenia[Ref]


Frequency not reported: Stevens-Johnson syndrome, urticaria, contact dermatitis (including allergic contact dermatitis), rash, skin exfoliation, lichenoid keratosis, pruritus, erythema of eyelid, eyelid eczema, alopecia, psoriasiform rash, exacerbation of psoriasis[Ref]


Frequency not reported: Hypoglycemia, masked symptoms of hypoglycemia in insulin-dependent diabetics[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Betagan Liquifilm (levobunolol)." Allergan Inc, Irvine, CA.

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