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Benicar HCT Side Effects

Generic Name: hydrochlorothiazide / olmesartan

Note: This page contains information about the side effects of hydrochlorothiazide / olmesartan. Some of the dosage forms included on this document may not apply to the brand name Benicar HCT.

Not all side effects for Benicar HCT may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to hydrochlorothiazide / olmesartan: oral tablet

In addition to its needed effects, some unwanted effects may be caused by hydrochlorothiazide / olmesartan. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking hydrochlorothiazide / olmesartan:

Less common
  • Bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • blurred vision
  • chest pain
  • difficult, burning, or painful urination
  • flushed, dry skin
  • frequent urge to urinate
  • fruit-like breath odor
  • increased hunger
  • increased urination
  • joint pain, stiffness, or swelling
  • lower back, side, or stomach pain
  • rapid weight gain
  • sweating
  • swelling of the feet or lower legs
  • tingling of the hands or feet
  • troubled breathing
  • unexplained weight loss
  • unusual weight gain or loss
Rare
  • Swelling or puffiness of the face
Incidence not known
  • Convulsions
  • decrease in the amount of urine
  • diarrhea (severe) with weight loss
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • rash

Some of the side effects that can occur with hydrochlorothiazide / olmesartan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Back pain
  • body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • ear congestion or pain
  • fever
  • headache
  • head congestion
  • hoarseness or other voice changes
  • loss of voice
  • runny or stuffy nose
  • sneezing
  • sore throat
Less common
  • Acid or sour stomach
  • belching
  • difficulty with moving
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • heartburn
  • indigestion
  • joint pain, stiffness, or swelling
  • loss of appetite
  • muscle pain or stiffness
  • pain, swelling, or redness in the joints
  • sensation of spinning
  • stomach discomfort or upset
  • weakness
Incidence not known
  • Diarrhea
  • muscle pain or stiffness
  • nervousness
  • weakness or heaviness of the legs

For Healthcare Professionals

Applies to hydrochlorothiazide / olmesartan: oral tablet

General

The most common side effect was dizziness.[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache
Uncommon (0.1% to 1%): Syncope

Hydrochlorothiazide:
Common (1% to 10%): Dizziness, headache
Postmarketing reports: Lightheadedness, paresthesia

Olmesartan:
Common (1% to 10%): Dizziness, headache[Ref]

Respiratory

Common (1% to 10%): Bronchitis, pharyngitis, sinusitis, upper respiratory tract infection, coughing, nasopharyngitis

Hydrochlorothiazide:
Common (1% to 10%): Bronchitis, nasopharyngitis, pharyngitis
Uncommon (0.1% to 1%): Sinusitis, upper respiratory tract infection, cough
Frequency not reported: Pneumonitis, pulmonary edema

Olmesartan:
Common (1% to 10%): Bronchitis, nasopharyngitis, sinusitis, upper respiratory tract infection, cough, pharyngitis, rhinitis[Ref]

Other

Common (1% to 10%): Vertigo, Influenza-like symptoms, chest pain, fatigue, peripheral edema
Uncommon (0.1% to 1%): Weakness
Postmarketing reports: Asthenia, lethargy, malaise

Hydrochlorothiazide:
Common (1% to 10%): Vertigo, influenza-like symptoms
Uncommon (0.1% to 1%): Chest pain, fatigue, peripheral edema
Frequency not reported: Weakness, fever

Olmesartan:
Common (1% to 10%): Vertigo, chest pain, fatigue, influenza-like symptoms, peripheral edema, pain
Postmarketing reports: Asthenia, lethargy, malaise[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, gastroenteritis, nausea, abdominal pain, dyspepsia
Postmarketing reports: Sprue-like enteropathy, vomiting

Hydrochlorothiazide:
Uncommon (0.1% to 1%): Diarrhea, dyspepsia, nausea, gastroenteritis
Frequency not reported: Sialadenitis, cramping, gastric irritation
Postmarketing reports: Constipation

Olmesartan:
Common (1% to 10%): Diarrhea, dyspepsia, nausea, gastroenteritis, abdominal pain
Postmarketing reports: Vomiting, sprue-like enteropathy[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, creatine phosphokinase increased, arthralgia, arthritis, myalgia
Uncommon (0.1% to 1%): Pain in limb, spinal disorder
Postmarketing reports: Rhabdomyolysis

Hydrochlorothiazide:
Common (1% to 10%): Arthralgia, back pain, pain in limb
Uncommon (0.1% to 1%): Spinal disorder
Frequency not reported: Muscle spasm

Olmesartan:
Common (1% to 10%): Arthralgia, back pain, pain in limb, arthritis, skeletal pain, creatine phosphokinase increased
Uncommon (0.1% to 1%): Spinal disorder, myalgia
Postmarketing reports: Rhabdomyolysis[Ref]

Metabolic

Common (1% to 10%): Hyperlipemia, hyperglycemia, blood uric acid increased, hyperuricemia
Uncommon (0.1% to 1%): Blood glucose increased, blood potassium decreased, blood potassium increased, hypertriglyceridemia
Postmarketing reports: Hyperkalemia

Hydrochlorothiazide:
Common (1% to 10%): Blood glucose increased, blood potassium decreased
Uncommon (0.1% to 1%): Blood uric acid increased
Frequency not reported: Hyperglycemia, glycosuria, hyperuricemia
Postmarketing reports: Anorexia, loss of appetite

Olmesartan:
Common (1% to 10%): Hypertriglyceridemia, hyperglycemia, hyperuricemia
Uncommon (0.1% to 1%): Blood glucose increased, blood potassium decreased, blood uric acid increased
Rare (less than 0.1%): Hyperkalemia
Frequency not reported: Hypercholesterolemia[Ref]

Hepatic

Common (1% to 10%): GGT increased, AST increased, ALT increased

Hydrochlorothiazide:
Uncommon (0.1% to 1%): ALT increased, AST increased, GGT increased
Frequency not reported: Pancreatitis, intrahepatic cholestatic jaundice

Olmesartan:
Common (1% to 10%): ALT increased, AST increased, GGT increased[Ref]

Genitourinary

Common (1% to 10%): Hematuria, urinary tract infection

Hydrochlorothiazide:
Common (1% to 10%): Urinary tract infection

Olmesartan:
Common (1% to 10%): Urinary tract infection, hematuria[Ref]

Psychiatric

Uncommon (0.1% to 1%): Anxiety, insomnia

Hydrochlorothiazide:
Uncommon (0.1% to 1%): Anxiety, insomnia
Frequency not reported: Restlessness
Postmarketing reports: Sleep disturbances, depression

Olmesartan:
Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Anxiety[Ref]

Dermatologic

Common (1% to 10%): Rash, facial edema
Uncommon (0.1% to 1%): Eczema
Postmarketing reports: Alopecia, pruritus, urticaria

Hydrochlorothiazide:
Frequency not reported: Purpura, photosensitivity, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis
Postmarketing reports: Rash, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus, erythematosus

Olmesartan:
Uncommon (0.1% to 1%): Rash
Postmarketing reports: Alopecia, pruritus, urticaria[Ref]

Immunologic

Common (1% to 10%): Influenza
Uncommon (0.1% to 1%): Viral infection
Frequency not reported: Angioedema
Postmarketing reports: Anaphylactic reactions

Hydrochlorothiazide:
Uncommon (0.1% to 1%): Influenza, viral infection
Frequency not reported: Anaphylactic reactions

Olmesartan:
Common (1% to 10%): Influenza
Uncommon (0.1% to 1%): Viral infection
Postmarketing reports: Angioedema, anaphylactic reactions[Ref]

Renal

Uncommon (0.1% to 1%): Blood creatinine increased
Postmarketing reports: Acute renal failure

Hydrochlorothiazide:
Uncommon (0.1% to 1%): Blood creatinine increased
Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis

Olmesartan:
Uncommon (0.1% to 1%): Blood creatinine increased
Postmarketing reports: Acute renal failure[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Palpitations, hypotension, orthostatic hypotension

Hydrochlorothiazide:
Frequency not reported: Vasculitis, cutaneous vasculitis
Postmarketing reports: Cardiac arrhythmias, postural hypotension

Olmesartan:
Uncommon (0.1% to 1%): Tachycardia, angina pectoris
Rare (less than 0.1%): Hypotension[Ref]

Hematologic

Hydrochlorothiazide:
Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia
Postmarketing reports: Bone marrow depression[Ref]

Ocular

Ocular side effects have included idiosyncratic reactions to the hydrochlorothiazide component resulting in acute transient myopia and acute angle-closure glaucoma.[Ref]

References

1. "Product Information. Benicar HCT (hydrochlorothiazide-olmesartan)." Sankyo Parke Davis, Parsippany, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

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