Atovaquone and proguanil Side Effects
Please note - some side effects for Atovaquone and proguanil may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects by Body System - for Healthcare Professionals
Applies to: oral tablet
In general, side effects associated with the use of atovaquone-proguanil have been mild. Side effects are more pronounced and occur more frequently when higher doses are used in the treatment of malaria than with lower prophylactic doses.
Dermatologic side effects have included pruritus (2%). Cutaneous reactions ranging from rash, photosensitivity, and urticaria have been reported during postmarketing experience.
Gastrointestinal side effects have included abdominal pain (5% to 17%), nausea (3% to 12%), vomiting (1% to 12%), diarrhea (4% to 8%), mouth ulcers (6%), anorexia (5%), dyspepsia (2%), and gastritis (2%). GI upset has also been reported. Stomatitis has been reported during postmarketing experience.
Hepatic side effects have included transient increases in liver function tests. These increases have not required discontinuation of therapy. Rare cases of hepatitis, cholestasis, and a single case of hepatic failure have been reported during postmarketing experience.
Musculoskeletal side effects have included asthenia (8%), myalgia (7%), and back pain (4%).
Nervous system side effects have included headache (4% to 17%), dizziness (2% to 5%), vertigo (2%), and visual disturbances (2%). Rare cases of seizures and psychotic events (such as hallucinations) have been reported during postmarketing experience. However, a causal relationship has not been established.
Respiratory side effects have rarely included cough (4%).
Hypersensitivity side effects have included rare cases of anaphylaxis. Rare cases of erythema multiforme, Stevens-Johnson syndrome, vasculitis, and angioedema have been reported during postmarketing experience.
Psychiatric side effects including strange or vivid dreams (7%), insomnia (3%), anxiety (less than 1%), and depression (less than 1%) have been reported.
Hematologic side effects including neutropenia, anemia (rarely), and pancytopenia in patients with severe renal impairment treated with proguanil have been reported during the postmarketing experience.
Other side effects have included flu-like symptoms (4%) and fever (3%).Top
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