Medication Guide App

Atacand HCT Side Effects

Generic Name: candesartan / hydrochlorothiazide

Note: This page contains information about the side effects of candesartan / hydrochlorothiazide. Some of the dosage forms included on this document may not apply to the brand name Atacand HCT.

Not all side effects for Atacand HCT may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to candesartan / hydrochlorothiazide: oral tablet

Along with its needed effects, candesartan / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking candesartan / hydrochlorothiazide:

Less common
  • Cough
  • dizziness
  • dryness of the mouth
  • fever
  • increased thirst
  • irregular heartbeat
  • lightheadedness
  • muscle cramps
  • nausea
  • sore throat
  • unusual tiredness
  • vomiting
  • weak pulse
  • weakness
Rare
  • Arm pain
  • chest pain
  • chest tightness
  • fast or irregular heartbeat
  • large, hive like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • shortness of breath

Some side effects of candesartan / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Back pain
  • diarrhea
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • runny nose
  • sneezing
  • sweating
  • trouble sleeping

For Healthcare Professionals

Applies to candesartan / hydrochlorothiazide: oral tablet

Respiratory

Respiratory side effects associated with candesartan-hydrochlorothiazide have included upper respiratory tract infection (3.6%), bronchitis, sinusitis, pharyngitis, coughing, rhinitis, and dyspnea. Respiratory distress, pneumonitis, and pulmonary edema have been reported with the use of HCTZ.

Nervous system

Nervous system side effects associated with candesartan-hydrochlorothiazide have included dizziness (2.9%), vertigo, paresthesia, and hypesthesia. Restlessness has been reported with the use of HCTZ.

Musculoskeletal

Musculoskeletal side effects associated with candesartan-hydrochlorothiazide have included arthralgia, myalgia, arthrosis, arthritis, leg cramps, and sciatica. Muscle spasm has been reported with the use HCTZ.

Musculoskeletal side effects associated with angiotensin II receptor blockers including rare reports of rhabdomyolysis have been reported during postmarketing experience.

Gastrointestinal

Gastrointestinal side effects associated with candesartan-hydrochlorothiazide have included nausea, abdominal pain, diarrhea, dyspepsia, gastritis, gastroenteritis, and vomiting. Pancreatitis, jaundice (intrahepatic cholestatic jaundice), sialadenitis, cramping, constipation, gastric irritation, and anorexia have been reported with the use of HCTZ.

Metabolic

Metabolic side effects associated with candesartan-hydrochlorothiazide have included hyperuricemia, hyperglycemia, hypokalemia, increased BUN, and increased creatine phosphokinase. Electrolyte imbalance and glycosuria have been reported with the use of HCTZ.

Metabolic side effects associated with candesartan have included hypertriglyceridemia.

Hepatic

Hepatic side effects associated with candesartan-hydrochlorothiazide have included abnormal hepatic function, increased transaminase levels, and hepatitis.

Cardiovascular

Cardiovascular side effects associated with candesartan-hydrochlorothiazide have included tachycardia, palpitation, extrasystoles, bradycardia, and ECG abnormalities. Angina pectoris, myocardial infarction, and angioedema have been reported in less than 0.5% of patients. Hypotension, orthostatic hypotension, and necrotizing angiitis (vasculitis and cutaneous vasculitis) have been reported with the use of HCTZ.

Psychiatric

Psychiatric side effects associated with candesartan-hydrochlorothiazide have included depression, insomnia, and anxiety. Somnolence has been reported with the use of candesartan.

Dermatologic

Dermatologic side effects associated with candesartan-hydrochlorothiazide have included eczema, increased sweating, pruritus, and dermatitis. Photosensitivity, urticaria, purpura, exfoliative dermatitis, toxic epidermal necrolysis, and alopecia have been reported with the use of HCTZ.

Hematologic

Hematologic side effects associated with candesartan-hydrochlorothiazide have included epistaxis. Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, and thrombocytopenia have been reported with the use of HCTZ.

Immunologic

Immunologic side effects associated with candesartan-hydrochlorothiazide have included infection and viral infection.

Ocular

Ocular side effects associated with candesartan-hydrochlorothiazide have included conjunctivitis. Transient blurred vision and xanthopsia have been reported with the use of hydrochlorothiazide. FDA has received reports of idiosyncratic reactions to the hydrochlorothiazide component resulting in acute transient myopia and acute angle-closure glaucoma.

Other

Other side effects associated with candesartan-hydrochlorothiazide have included back pain (3.3%), influenza-like symptoms fatigue, pain, peripheral edema, asthenia fever, and tinnitus. Weakness has been reported with the use of HCTZ.

Renal

Renal side effects associated with candesartan-hydrochlorothiazide have included urinary tract infection, hematuria, and cystitis. Renal failure, renal dysfunction, and interstitial nephritis have been reported with the use of HCTZ.

Renal side effects associated with candesartan have included albuminuria.

Genitourinary

Genitourinary side effects associated with HCTZ have included impotence.

Hypersensitivity

Hypersensitivity side effects associated with HCTZ have included erythema multiforme and Stevens-Johnson syndrome.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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