Asendin Side Effects

Generic Name: amoxapine

Note: This page contains information about the side effects of amoxapine. Some of the dosage forms included on this document may not apply to the brand name Asendin.

Not all side effects for Asendin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to amoxapine: oral tablet

In addition to its needed effects, some unwanted effects may be caused by amoxapine (the active ingredient contained in Asendin). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking amoxapine:

Less common
  • Excitement
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fear or nervousness
  • mood or mental changes
  • nightmares
  • restlessness
  • shakiness and unsteady walk
  • shakiness in legs, arms, hands, or feet
  • sleeplessness
  • swelling
  • trouble sleeping
  • unable to sleep
  • unsteadiness, trembling, or other problems with muscle control or coordination
Rare
  • Abdominal or stomach pain
  • actions that are out of control
  • black, tarry stools
  • bleeding gums
  • bloating
  • blood in urine or stools
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chills
  • clay-colored stools
  • confusion
  • confusion about identity, place, and time
  • constipation
  • continuing ringing or buzzing or other unexplained noise in ears
  • convulsions
  • cough or hoarseness
  • dark urine
  • decrease in frequency of urination
  • decrease in urine volume
  • difficulty in breathing
  • difficulty in passing urine (dribbling)
  • difficulty in speaking
  • disturbed concentration
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • double vision
  • drooling
  • extremely high fever or body temperature
  • false beliefs that cannot be changed by facts
  • fast, weak heartbeat
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • hearing loss
  • high fever
  • high or low blood pressure
  • hives or welts
  • inability to move arms, legs, or facial muscles
  • inability to speak
  • increased need to urinate
  • increased sweating
  • indigestion
  • irritability
  • itching
  • lack of coordination
  • light-colored stools
  • lip smacking or puckering
  • loss of appetite
  • loss of bladder control
  • lower back or side pain
  • muscle cramps
  • muscle spasm or jerking of all extremities
  • muscle trembling, jerking, or stiffness
  • nausea and vomiting
  • nervousness
  • numbness
  • pain or discomfort in arms, jaw, back, or neck
  • painful or difficult urination
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • pale, clammy skin
  • passing urine more often
  • pinpoint red spots on skin
  • pounding in the ears
  • puffing of cheeks
  • rapid or worm-like movements of tongue
  • redness of skin
  • seeing, hearing, or feeling things that are not there
  • severe muscle stiffness
  • shortness of breath
  • shuffling walk
  • skin rash
  • slow speech
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • stiffness of limbs
  • sudden loss of consciousness
  • sweating
  • swollen glands
  • talking, feeling, and acting with excitement
  • testicular swelling
  • thirst
  • trouble in holding or releasing urine
  • twisting movements of body
  • uncontrolled chewing movements
  • uncontrolled movements, especially of face, neck, and back
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusually pale skin
  • upper right abdominal pain
  • vomiting of blood
  • yellow eyes and skin

If any of the following symptoms of overdose occur while taking amoxapine, get emergency help immediately:

Symptoms of overdose
  • Change in consciousness
  • drowsiness
  • epileptic seizure that will not stop
  • fatigue
  • increased blood pressure
  • increased thirst
  • loss of consciousness
  • swelling of face, fingers, or lower legs
  • total body jerking
  • troubled breathing
  • weight gain

Some of the side effects that can occur with amoxapine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Dry mouth
Less common
  • Increased appetite
  • increased flow of breast milk
Rare
  • Agitation
  • breast enlargement
  • change in taste bad unusual or unpleasant (after)taste
  • decreased interest in sexual intercourse
  • depression
  • excess air or gas in stomach or intestines
  • full feeling
  • hair loss, thinning of hair
  • heartburn
  • inability to have or keep an erection
  • increased in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse
  • increased sensitivity of skin to sunlight
  • loss in sexual ability, desire, drive, or performance
  • menstrual changes
  • nasal stuffiness
  • painful ejaculation
  • passing gas
  • rapid weight gain
  • redness or other discoloration of skin
  • seizures
  • severe sunburn
  • stupor
  • swollen, painful, or tender lymph glands on side of face or neck
  • tearing of the eyes
  • unexpected or excess milk flow from breasts

For Healthcare Professionals

Applies to amoxapine: oral tablet

Nervous system

Nervous system side effects have included drowsiness (14%), anxiety, dizziness, headache, fatigue, weakness, insomnia, sleep abnormalities, restlessness, nervousness, tremors, confusion, excitement, nightmares, and alterations in the EEG patterns.

Nearly all selective serotonin reuptake inhibitors, mixed serotonin/norepinephrine reuptake inhibitors, and tricyclic antidepressants cause sleep abnormalities to some extent. These antidepressants have marked dose-dependent effects on rapid eye movement (REM) sleep, causing reductions in the overall amount of REM sleep over the night and delays the first entry into REM sleep (increased REM sleep onset latency (ROL)), both in healthy subjects and depressed patients. The antidepressants that increase serotonin function appear to have the greatest effect on REM sleep. The reduction in REM sleep is greatest early in treatment, but gradually returns towards baseline during long-term therapy; however, ROL remains long. Following discontinuation of therapy the amount of REM sleep tends to rebound. Some of these drugs (i.e., bupropion, mirtazapine, nefazodone, trazodone, trimipramine) appear to have a modest or minimal effect on REM sleep.

Gastrointestinal

Gastrointestinal side effects have included dry mouth (14%), constipation (12%), nausea, and excessive appetite.

Ocular

Ocular side effects have included blurred vision (7%).

Cardiovascular

Cardiovascular side effects have included palpitations.

Musculoskeletal

Musculoskeletal side effects have included ataxia.

Hypersensitivity

Hypersensitivity side effects have included edema.

Dermatologic

Dermatologic side effects have included excessive perspiration and skin rash.

Endocrine

Endocrine side effects have included elevation of prolactin levels and hyponatremia (in association with the syndrome of inappropriate secretion of antidiuretic hormone).

A retrospective register study of the World Health Organization (WHO) database for spontaneous reporting of adverse drug reactions (n=668) suggests that the risk of hyponatremia during treatment with antidepressants seems to be highest in women, in the elderly, during the summer season, and during the first weeks of therapy.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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