Arixtra 10 mg / dose Side Effects

Generic Name: fondaparinux

Note: This page contains information about the side effects of fondaparinux. Some of the dosage forms included on this document may not apply to the brand name Arixtra 10 mg / dose.

Not all side effects for Arixtra 10 mg / dose may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to fondaparinux: subcutaneous solution

In addition to its needed effects, some unwanted effects may be caused by fondaparinux (the active ingredient contained in Arixtra 10 mg / dose). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking fondaparinux:

More common
  • Pale skin
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Black, tarry stools
  • bladder pain
  • bleeding
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • chest pain
  • chills
  • collection of blood under the skin
  • confusion
  • convulsions
  • cough
  • decreased or cloudy urine
  • deep, dark purple bruise
  • difficult, burning, or painful urination
  • dizziness
  • dry mouth
  • fainting or lightheadedness when getting up from a lying or sitting position
  • fever
  • frequent urge to urinate
  • increased thirst
  • irregular heartbeat
  • itching, pain, redness, or swelling at the place of injection
  • loss of appetite
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • pinpoint red spots on the skin
  • red, tender, or oozing skin at incision
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sudden sweating

If any of the following symptoms of overdose occur while taking fondaparinux, get emergency help immediately:

Symptoms of overdose
  • Abdominal or stomach pain or swelling
  • bruising or purple areas on the skin
  • coughing up blood
  • decreased alertness
  • headache
  • joint pain or swelling
  • nosebleeds

Some of the side effects that can occur with fondaparinux may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Difficulty having a bowel movement
  • rash
  • sleeplessness
  • swelling
  • trouble sleeping
Less common
  • Acid or sour stomach
  • belching
  • diarrhea
  • heartburn
  • indigestion
  • pain
  • skin blisters
  • stomach discomfort, upset, or pain
  • tightness in the chest
  • unusual changes to site of surgery
  • wheezing
  • wound drainage, increased

For Healthcare Professionals

Applies to fondaparinux: subcutaneous solution

Hematologic

Hematologic side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra 10 mg / dose) have included major bleeding, anemia, purpura, thrombocytopenia, postoperative hemorrhage and hematoma. Occurrences of major bleeding in patients receiving therapeutic regimen in treatment of DVT and PE with normal renal function, mild renal impairment, moderate renal impairment, and severe renal impairment have been found to be 0.4%, 1.6%, 2.2%, and 7.3%, respectively. Moderate thrombocytopenia occurred at a rate of 0.5% in patients given fondaparinux treatment regimen in the DVT and PE treatment clinical trials. Severe thrombocytopenia occurred at a rate of 0.04% in patients given fondaparinux treatment regimen in the DVT and PE treatment clinical trials.

Rare cases of elevated aPTT and heparin-induced thrombocytopenia have been reported. A causal relationship of these events to fondaparinux has not been established.

Hepatic

Hepatic side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra 10 mg / dose) have included elevated aminotransferase levels.

Local

Local side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra 10 mg / dose) have included injection site bleeding, rash, and pruritus.

Gastrointestinal

Gastrointestinal side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra 10 mg / dose) have included nausea, vomiting, constipation, diarrhea, and dyspepsia.

Nervous system

Nervous system side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra 10 mg / dose) have included insomnia, dizziness, and confusion.

Dermatologic

Dermatologic side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra 10 mg / dose) have included rash, increased wound drainage, and bullous eruption.

Cardiovascular

Cardiovascular side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra 10 mg / dose) have included hypotension and edema.

Genitourinary

Genitourinary side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra 10 mg / dose) have included urinary tract infection and urinary retention.

Metabolic

Metabolic side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra 10 mg / dose) have included hypokalemia.

Other

Other side effects associated with the administration of fondaparinux (the active ingredient contained in Arixtra 10 mg / dose) have included fever, headache, and pain.

Hypersensitivity

Hypersensitivity side effects include postmarketing reports of serious allergic reactions including angioedema and anaphylactoid/anaphylactic reactions.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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