Aridol Side Effects
Generic Name: mannitol
Note: This page contains information about the side effects of mannitol. Some of the dosage forms included on this document may not apply to the brand name Aridol.
Not all side effects for Aridol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to mannitol: inhalation capsule
In addition to its needed effects, some unwanted effects may be caused by mannitol (the active ingredient contained in Aridol). In the event that any of these side effects do occur, they may require medical attention.
If any of the following side effects occur while taking mannitol, check with your doctor or nurse immediately:Less common
- Chest discomfort
- difficult or labored breathing
- dry heaves
- runny nose
- shortness of breath
- sore throat
- tightness in the chest
- troubled breathing
Some of the side effects that can occur with mannitol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common
- sore throat
For Healthcare Professionals
Applies to mannitol: compounding powder, inhalation kit, intravenous solution, irrigation solution
Cardiovascular side effects have included hypotension and tachycardia. Venous thrombosis or phlebitis extending from the injection site and hypervolemia have occurred rarely and are generally associated with the solution or technique used in administration.
Respiratory side effects have included pulmonary congestion and rhinitis. Respiratory side effects associated with mannitol (the active ingredient contained in Aridol) inhalation have included cough, gagging, wheeze, and decreased forced expiratory volume.
Metabolic side effects have included fluid and electrolyte imbalance, acidosis, and electrolyte loss.
Nervous system side effects have included headache, convulsions, and dizziness.
Hematologic side effects have included thrombophlebitis.
Eight cases of mannitol (the active ingredient contained in Aridol) IV overdose in patients with preexisting renal failure were reviewed. Symptoms presented in the reviewed cases were CNS involvement out of proportion to uremia, severe hyponatremia, large osmolality gap, and fluid overload. Six patients were treated with hemodialysis, one patient with peritoneal dialysis, and one patient died before initiation of treatment. All patients received large doses over 1 to 3 days with a mean dose of 310 +/- 182.8 g. CNS involvement consisted of CNS depression, confusion, lethargy, stupor, and coma. Two patients recovered cerebral function and continued on lifetime dialysis, 3 patients recovered renal and cerebral function, and 1 patient recovered renal function but had severe cerebral dysfunction.
Other side effects have included dryness of mouth, thirst, edema, arm pain, chills, dehydration, fever, mannitol intoxication, and angina-like pain.
Renal side effects have included acute renal failure.
Local side effects have included extravasation. This effect is generally attributed to the solution or technique used in administration.
Dermatologic side effects have included urticaria and skin necrosis.
Ocular side effects have included blurred vision.
Immunologic side effects have included infection at the injection site and febrile response. These effects are usually attributed to solution or technique used in administration.
Gastrointestinal side effects have included nausea and vomiting.
Genitourinary side effects have included marked diuresis and urinary retention.
A 75-year-old woman with severe major depression experienced a manic episode 30 minutes after initiation of a 20% mannitol (the active ingredient contained in Aridol) intravenous infusion for the treatment of acute angle closure glaucoma. The patient had been started on nortriptyline 50 mg per day for the treatment of depression ten days earlier. She received oral acetazolamide, topical pilocarpine, topical timolol, and topical dexamethasone concomitantly for the treatment of glaucoma. The mania resolved within approximately 1 hour following discontinuation of the mannitol infusion, and the patient returned to a severe depressive state. An extensive lab evaluation, toxicology screening, and medical examination failed to show additional secondary causes for mania in this patient.
Psychiatric side effects have rarely included mania (1 case report).
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- Other brands: Osmitrol
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