Anastrozole Side Effects
Some side effects of anastrozole may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to anastrozole: oral tablet
Along with its needed effects, anastrozole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking anastrozole:More common
- Blurred vision
- chest pain or discomfort
- pounding in the ears
- shortness of breath
- slow or fast heartbeat
- swelling of the feet or lower legs
- Arm, back, or jaw pain
- chest tightness or heaviness
- cough or hoarseness
- difficult or painful urination
- dizziness, severe
- fever or chills
- headache, continuing
- increased blood pressure
- lower back or side pain
- pain, tenderness, bluish color, or swelling of the foot or leg
- sore throat
- sudden shortness of breath
- unusual tiredness or weakness
- vaginal bleeding (unexpected and heavy)
- Blistering, peeling, or loosening of the skin
- itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- red skin lesions, often with a purple center
- sores, ulcers, or white spots in the mouth or on the lips
Some side effects of anastrozole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Acid or sour stomach
- back pain
- body aches or pain
- bone pain
- decrease in height
- dry mouth
- dryness or soreness of the throat
- feeling of warmth
- flushing or redness of the skin, especially on the face and neck
- hot flashes
- increased appetite
- lack or loss of strength
- loss of appetite
- mood or mental changes
- pain in the back, ribs, arms, or legs
- pain, general
- pelvic pain
- runny nose
- skin rash
- stomach discomfort, upset, or pain
- tender, swollen glands in the neck
- trouble in swallowing
- voice changes
- weight loss
- Anxiety and confusion
- breast pain
- cough producing mucus
- difficulty breathing
- dryness of the vagina
- general feeling of discomfort or illness
- itching of the skin
- joint pain and stiffness
- loss of hair
- muscle pain
- numbness or tingling of the hands or feet
- sleepiness or unusual drowsiness
- trouble sleeping or sleeplessness
- weight gain
For Healthcare Professionals
Applies to anastrozole: compounding powder, oral tablet
Gastrointestinal side effects (up to 33%) have included nausea (up to 20%), vomiting (up to 11%), diarrhea (up to 8%), constipation (up to 8%), and abdominal pain (up to 8%).
Other side effects have included headache (up to 18%), hot flushes (up to 13%), pain (up to 15%), and chest pain (up to 7%).
General side effects have included asthenia (up to 16%).
Musculoskeletal side effects have included arthritis (up to 17%), arthralgia (up to 15%), bone pain (up to 12%), osteoporosis (up to 11%), fracture (up to 10%), and back pain (up to 11%).
Postmarketing musculoskeletal side effects have included myalgia and trigger finger.
Respiratory side effects have included dyspnea (up to 11%), pharyngitis (up to 9%), increased cough (up to 8%), and dry mouth (up to 6%).
Cardiovascular side effects have included hypertension (up to 13%), edema (up to 11%), including peripheral edema (up to 9%). Ischemic cardiovascular disease (4%) has also been reported.
Genitourinary side effects include pelvic pain (up to 7%).
Dermatologic side effects have included rash (up to 11%) and alopecia. Henoch-Schonlein purpura has been reported. A case of subacute cutaneous lupus erythematosus has also been reported.
Postmarketing dermatologic side effects have included rash including mucocutaneous disorders such as erythema multiforme and Stevens-Johnson syndrome.
Nervous system side effects have included insomnia (up to 10%), dizziness (up to 6%), paresthesia (up to 6%), and carpal tunnel syndrome.
Psychiatric side effects have included depression (up to 5%).
Hepatic side effects have been reported including a case of severe acute hepatitis in a patient treated with anastrozole.
Postmarketing hepatic side effects have included hepatitis, and increases in alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, gamma-GT, and bilirubin.
Hematologic side effects have included lymphedema (10%) and anemia (4%).
Metabolic side effects have included hypercholesterolemia (up to 9%).
Postmarketing metabolic side effects have included hypercalcemia (with or without an increase in parathyroid hormone).
Postmarketing hypersensitivity side effects have included allergic reactions including angioedema, urticaria, and anaphylaxis.
More anastrozole resources
- anastrozole Advanced Consumer (Micromedex) - Includes Dosage Information
- anastrozole MedFacts Consumer Leaflet (Wolters Kluwer)
- Anastrozole Prescribing Information (FDA)
- Anastrozole Professional Patient Advice (Wolters Kluwer)
- Anastrozole Monograph (AHFS DI)
- Arimidex Prescribing Information (FDA)
- Arimidex Consumer Overview
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