Amitriptyline / perphenazine Side Effects

Some side effects of amitriptyline / perphenazine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Applies to amitriptyline / perphenazine: oral tablet

Along with its needed effects, perphenazine (included in this combination medicine) can sometimes cause serious side effects. Tardive dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia include fine, worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, or arms and legs. Other serious but rare side effects may also occur. These include severe muscle stiffness, fever, unusual tiredness or weakness, fast heartbeat, difficult breathing, increased sweating, loss of bladder control, and seizures (neuroleptic malignant syndrome). You and your doctor should discuss the good this medicine will do as well as the risks of taking it.

Stop taking amitriptyline / perphenazine and get emergency help immediately if any of the following effects occur:

Rare
  • Convulsions (seizures)
  • difficulty in breathing
  • fast heartbeat
  • fever
  • high or low blood pressure
  • increased sweating
  • loss of bladder control
  • muscle stiffness (severe)
  • unusual tiredness or weakness
  • unusually pale skin

Check with your doctor as soon as possible if any of the following side effects occur while taking amitriptyline / perphenazine:

More common
  • Blurred vision or any change in vision
  • difficulty in speaking or swallowing
  • fainting
  • inability to move eyes
  • lip smacking or puckering
  • loss of balance control
  • mask-like face
  • muscle spasms, especially of face, neck, and back
  • nervousness, restlessness, or need to keep moving
  • puffing of cheeks
  • rapid or fine, worm-like movements of tongue
  • shuffling walk
  • stiffness of arms and legs
  • trembling and shaking of fingers and hands
  • tic-like or twitching movements
  • twisting movements of body
  • uncontrolled chewing movements
  • uncontrolled movements of arms or legs
  • weakness of arms and legs
Less common
  • Confusion
  • constipation
  • difficult urination
  • eye pain
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • increased skin sensitivity to sun
  • shakiness
  • slow pulse or irregular heartbeat
Rare
  • Abdominal or stomach pain
  • aching muscles or joints
  • back or leg pain
  • fever and chills
  • hair loss
  • hot, dry skin or lack of sweating
  • irritability
  • loss of appetite
  • muscle weakness or twitching
  • nausea, vomiting, or diarrhea
  • nosebleeds
  • prolonged, painful, inappropriate penile erection
  • ringing, buzzing, or other unexplained noises in ears
  • skin discoloration
  • skin rash and itching
  • sore throat and fever
  • swelling of face and tongue
  • swelling of testicles
  • unusual bleeding or bruising
  • yellow eyes or skin
Symptoms of overdose
  • Agitation
  • confusion
  • convulsions (seizures)
  • drowsiness (severe)
  • enlarged pupils
  • fast, slow, or irregular heartbeat
  • fever
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • shortness of breath or troubled breathing
  • unusual tiredness or weakness (severe)
  • vomiting (severe)

Some side effects of amitriptyline / perphenazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Decreased sweating
  • dizziness
  • drowsiness
  • dryness of mouth
  • headache
  • increased appetite for sweets
  • nasal congestion
  • tiredness or weakness (mild)
  • unpleasant taste
  • weight gain (unusual)
Less common
  • Changes in menstrual period
  • decreased sexual ability
  • heartburn
  • increased sweating
  • swelling or pain in breasts or unusual secretion of milk

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Dizziness
  • nausea or vomiting
  • stomach pain
  • trembling of fingers and hands
  • symptoms of tardive dyskinesia, including lip smacking or puckering, puffing of cheeks, rapid or fine, worm-like movements of tongue, uncontrolled chewing movements, or uncontrolled movements of arms or legs

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Diarrhea
  • headache
  • irritability
  • restlessness
  • trouble in sleeping, with vivid dreams
  • unusual excitement

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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