Amitriptyline / perphenazine Side Effects

Some side effects of amitriptyline / perphenazine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Applies to amitriptyline / perphenazine: oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking amitriptyline / perphenazine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

• restless muscle movements in your eyes, tongue, jaw, or neck;

• tremor (uncontrolled shaking);

• fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;

• feeling like you might pass out;

• seizures (convulsions);

• slow heart rate, chest pain or heavy feeling;

• easy bruising or bleeding;

• jaundice (yellowing of your skin or eyes);

• painful or difficult urination; or

• urinating less than usual or not at all.

Less serious side effects of amitriptyline / perphenazine may include:

• feeling dizzy, drowsy, or tired;

• strange dreams or nightmares;

• sleep problems (insomnia);

• dry mouth, loss of appetite;

• nausea, vomiting, diarrhea, constipation;

• blurred vision;

• breast changes; or

• decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

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