Aminocaproic Side Effects

Please note - some side effects for Aminocaproic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Aminocaproic - for the Consumer

Aminocaproic Acid

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Aminocaproic Acid:

Confusion; decreased vision; diarrhea; dizziness; fatigue or tiredness; general body discomfort; headache; lightheadedness; muscle aches or swelling; nausea; pain; ringing in the ears; stomach pain; stuffy nose; swelling; vomiting; watery eyes.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); delirium; fainting; fever; hallucinations; muscle pain or weakness; seizures; slow heartbeat; sore throat; stroke; sudden change in the amount of urine you are producing; swelling of ankles, feet, or hands; unusual bleeding or bruising.

Aminocaproic Acid Solution

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Aminocaproic Acid Solution:

Confusion; decreased vision; diarrhea; dizziness; fatigue or tiredness; general body discomfort; headache; injection site reaction (pain, redness, or swelling); lightheadedness; muscle aches; nausea; pain; ringing in the ears; stomach pain; stuffy nose; swelling; vomiting; watery eyes.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); delirium; fainting; fever; hallucinations; muscle pain or weakness; seizures; slow heartbeat; sore throat; stroke; sudden change in the amount of urine; swelling of ankles, feet, or hands; unusual bleeding or bruising.

Aminocaproic Acid Syrup

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Aminocaproic Acid Syrup:

Confusion; decreased vision; diarrhea; dizziness; fatigue or tiredness; general body discomfort; headache; lightheadedness; muscle aches or swelling; nausea; pain; ringing in the ears; stomach pain; stuffy nose; swelling; vomiting; watery eyes.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); delirium; fainting; fever; hallucinations; muscle pain or weakness; seizures; slow heartbeat; sore throat; stroke; sudden change in the amount of urine you are producing; swelling of ankles, feet, or hands; unusual bleeding or bruising.

Aminocaproic Side Effects - for the Professional

Aminocaproic

Aminocaproic acid is generally well tolerated. The following adverse experiences have been reported:

General: Edema, headache, malaise.

Hypersensitivity Reactions: Allergic and anaphylactoid reactions, anaphylaxis.

Local Reactions: Injection site reactions, pain and necrosis.

Cardiovascular: Bradycardia, hypotension, peripheral ischemia, thrombosis.

Gastrointestinal: Abdominal pain, diarrhea, nausea, vomiting.

Hematologic: Agranulocytosis, coagulation disorder, leukopenia, thrombocytopenia.

Musculoskeletal: CPK increased, muscle weakness, myalgia, myopathy, myositis, rhabdomyolysis.

Neurologic: Confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope.

Respiratory: Dyspnea, nasal congestion, pulmonary embolism.

Skin: Pruritis, rash.

Special Senses: Tinnitus, vision decreased, watery eyes.

Urogenital: BUN increased, renal failure. There have been some reports of dry ejaculation during the period of Aminocaproic acid treatment. These have been reported to date only in hemophilia patients who received the drug after undergoing dental surgical procedures. However, this symptom resolved in all patients within 24 to 48 hours of completion of therapy.

OVERDOSAGE

A few cases of acute overdosage with Aminocaproic acid administered intravenously have been reported. The effects ranged from no reaction to transient hypotension to severe acute renal failure leading to death. One patient with a history of brain tumor and seizures experienced seizures after receiving an 8 gram bolus injection of Aminocaproic acid. The single dose of Aminocaproic acid causing symptoms of overdosage or considered to be life-threatening is unknown. Patients have tolerated doses as high as 100 grams while acute renal failure has been reported following a dose of 12 grams.

The intravenous and oral LD50 of Aminocaproic acid were 3 and 12 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog. On intravenous administration, tonic-clonic convulsions were observed in dogs and mice.

No treatment for overdosage is known, although evidence exists that Aminocaproic acid is removed by hemodialysis and may be removed by peritoneal dialysis. Pharmacokinetic studies have shown that total body clearance of Aminocaproic acid is markedly decreased in patients with severe renal failure.

Side Effects by Body System

Hematologic

Hematologic side effects have included agranulocytosis, coagulation disorder, leukopenia, and thrombocytopenia.

Cardiovascular

Cardiovascular side effects have included bradycardia, hypotension, peripheral ischemia, and thrombosis.

Gastrointestinal

Gastrointestinal side effects have included abdominal pain, diarrhea, nausea, and vomiting.

Musculoskeletal

Musculoskeletal side effects have included increased levels of creatinine phosphokinase (CPK), muscle weakness, myalgia, myopathy, myositis, and rhabdomyolysis.

Nervous system

Nervous system side effects have included confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, and syncope.

Respiratory

Respiratory side effects have included dyspnea, nasal congestion, and pulmonary embolism.

Dermatologic

Dermatologic side effects have included pruritus and rash.

Renal

Renal side effects have included increased blood urea nitrogen (BUN) and renal failure.

Ocular

Ocular side effects have included decreased vision and watery eyes.

General

General side effects have included edema, headache, malaise, and tinnitus.

Hypersensitivity

Hypersensitivity side effects have included anaphylaxis, and allergic and anaphylactoid reactions.

Local

Local side effects have included injection site reactions, pain, and necrosis.

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