Ambrisentan Side Effects
Some side effects of ambrisentan may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to ambrisentan: oral tablet
Along with its needed effects, ambrisentan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ambrisentan:More common
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- rapid weight gain
- tingling of the hands or feet
- unusual weight gain or loss
- fast, irregular, pounding, or racing heartbeat or pulse
- muscle aches
- pain or tenderness around the eyes and cheekbones
- sore throat
- stuffy or runny nose
- tightness of the chest
- trouble breathing
- unusual tiredness or weakness
- Abdominal or stomach pain or tenderness
- chest pain
- clay colored stools
- dark urine
- decrease in the amount of urine
- decreased appetite
- dilated neck veins
- extreme fatigue
- irregular breathing
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- nausea and vomiting
- noisy, rattling breathing
- pale skin
- skin rash, itching
- troubled breathing at rest
- troubled breathing with exertion
- yellow skin or eyes
Get emergency help immediately if any of the following symptoms of overdose occur while taking ambrisentan:Symptoms of overdose
- Blurred vision
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
Some side effects of ambrisentan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- Difficulty having a bowel movement (stool)
- feeling of warmth
- redness of the face, neck, arms, and occasionally, upper chest
For Healthcare Professionals
Applies to ambrisentan: oral tablet
Hepatic side effects have included dose-dependent liver injury manifested primarily by elevation of serum aminotransferases (ALT or AST), but sometimes accompanied by abnormal liver function (elevated bilirubin). The combination of aminotransferases greater than 3 times the upper limit of normal and total bilirubin 2 times the upper limit of normal is a marker for potentially serious hepatic injury.
Hematologic side effects have included decreases in hemoglobin concentration and hematocrit. Postmarketing reports have included anemia. There have been postmarketing reports of decreases in hemoglobin concentration and hematocrit that have resulted in anemia requiring transfusion. In the long-term open-label extension of the two pivotal clinical studies, mean decreases from baseline (ranging from 0.9 to 1.2 g/dL) in hemoglobin concentrations persisted for up to 4 years of treatment.
Cardiovascular side effects have included peripheral edema, palpitations, and flushing. Fluid retention has been reported during postmarketing use of ambrisentan. Additional postmarketing reports have included heart failure (associated with fluid retention).
Respiratory side effects have included dyspnea, nasal congestion, sinusitis, and nasopharyngitis.
Gastrointestinal side effects have included abdominal pain and constipation. Postmarketing experience has included nausea and vomiting.
Nervous system side effects have included headache, asthenia, dizziness, and fatigue.
Hypersensitivity side effects have included postmarketing reports of angioedema and rash.
Postmarketing reports: Decreased sperm counts
More about ambrisentan
- Other brands: Letairis
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