Ambrisentan Side Effects
Some side effects of ambrisentan may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to ambrisentan: oral tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking ambrisentan: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
anxiety, sweating, pale skin, severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus, chest pain, fast or uneven heart rate;
swelling of the feet, ankles, or legs;
pounding heartbeats or fluttering in your chest; or
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
stuffy nose, sinus pain; or
flushing (warmth, redness, or tingly feeling).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to ambrisentan: oral tablet
Hepatic side effects have included dose-dependent liver injury manifested primarily by elevation of serum aminotransferases (ALT or AST), but sometimes accompanied by abnormal liver function (elevated bilirubin). The combination of aminotransferases greater than 3 times the upper limit of normal and total bilirubin 2 times the upper limit of normal is a marker for potentially serious hepatic injury.
Hematologic side effects have included decreases in hemoglobin concentration and hematocrit. Postmarketing reports have included anemia. There have been postmarketing reports of decreases in hemoglobin concentration and hematocrit that have resulted in anemia requiring transfusion. In the long-term open-label extension of the two pivotal clinical studies, mean decreases from baseline (ranging from 0.9 to 1.2 g/dL) in hemoglobin concentrations persisted for up to 4 years of treatment.
Cardiovascular side effects have included peripheral edema, palpitations, and flushing. Fluid retention has been reported during postmarketing use of ambrisentan. Additional postmarketing reports have included heart failure (associated with fluid retention).
Respiratory side effects have included dyspnea, nasal congestion, sinusitis, and nasopharyngitis.
Gastrointestinal side effects have included abdominal pain and constipation. Postmarketing experience has included nausea and vomiting.
Nervous system side effects have included headache, asthenia, dizziness, and fatigue.
Hypersensitivity side effects have included postmarketing reports of angioedema and rash.
More ambrisentan resources
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