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Amaryl Side Effects

Generic Name: glimepiride

Note: This page contains information about the side effects of glimepiride. Some of the dosage forms included on this document may not apply to the brand name Amaryl.

For the Consumer

Applies to glimepiride: oral tablet

In addition to its needed effects, some unwanted effects may be caused by glimepiride (the active ingredient contained in Amaryl). In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking glimepiride:

Rare
  • Difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing
Incidence not known
  • Abdominal or stomach pain
  • agitation
  • back, leg, or stomach pains
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloating of abdomen
  • blood in the urine or stools
  • bloody, black, or tarry stools
  • chest pain
  • chills
  • coma
  • confusion
  • cough or hoarseness
  • dark urine
  • decreased urine output
  • depression
  • diarrhea
  • difficulty with breathing
  • fever with or without chills
  • fluid-filled skin blisters
  • general body swelling
  • general tiredness and weakness
  • headache
  • high fever
  • hostility
  • irritability
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lethargy
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • muscle twitching
  • nausea and vomiting
  • nosebleeds
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • seizures
  • sensitivity to the sun
  • skin thinness
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stupor
  • swelling of face, ankles, or hands
  • swollen or painful glands
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking glimepiride, get emergency help immediately:

Symptoms of overdose
  • Anxiety
  • blurred vision
  • cold sweats
  • cool, pale skin
  • increased hunger
  • nightmares
  • shakiness
  • slurred speech

Severity: Minor

Some of the side effects that can occur with glimepiride may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Lack or loss of strength
Incidence not known
  • Redness or other discoloration of the skin
  • severe sunburn

For Healthcare Professionals

Applies to glimepiride: oral tablet

General

The most commonly reported adverse events included hypoglycemia, headache, nausea, asthenia, and dizziness.[Ref]

Metabolic

Hyponatremia and syndrome of inappropriate antidiuretic hormone secretion (SIADH) occurred in mostly in patients who were on other medications or who had medical conditions known to cause hyponatremia or increased release of antidiuretic hormone.[Ref]

Very common (10% or more): Hypoglycemia (up to 19.7%)
Frequency not reported: Weight gain
Postmarketing reports: Hyponatremia, SIADH[Ref]

Hematologic

Rare (less than 0.1%): Thrombocytopenia, leukopenia, agranulocytosis, granulocytopenia, erythropenia, aplastic anemia, pancytopenia
Postmarketing reports: Hemolytic anemia in patients without G6PD deficiency, thrombocytopenia purpura[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Allergic reactions such as pruritus, erythema, urticaria, a morbilliform or maculopapular eruptions
Frequency not reported: Cutaneous eruptions with or without pruritus, cross-allergenicity with sulfonylureas, sulfonamides, or related substances
Postmarketing reports: Anaphylaxis, angioedema, Stevens-Johnson syndrome, dyspnea[Ref]

Ocular

Temporary visual impairment due to changes in blood glucose levels may occur due to temporary alteration in the turgidity and hence the refractive index of the lens which is dependent on blood glucose levels.[Ref]

Frequency not reported: Transient visual disturbances[Ref]

Dermatologic

Dermatologic side effects have included pruritus, erythema, urticaria, and morbilliform or maculopapular rashes in less than 1% of cases. Sulfonylureas have caused porphyria cutanea tarda and photosensitivity reactions.[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness[Ref]

Gastrointestinal

Rare (less than 0.1%): Nausea, vomiting, diarrhea, abdominal discomfort, abdominal pain, sensations of pressure or fullness in the epigastrium[Ref]

Hepatic

Common (1% to 10%): Elevated ALT
Very rare (less than 0.01%): Hepatic function abnormal, hepatitis, hepatic failure
Postmarketing reports: Hepatitis and liver impairment, e.g. with cholestasis and jaundice, hepatic porphyria reactions and disulfiram-like reactions[Ref]

Immunologic

Common (1% to 10%): Flu syndrome
Very rare (less than 0.01%): Leukocytoclastic vasculitis[Ref]

Other

Common (1% to 10%): Asthenia, accidental injury[Ref]

Accidental injury was reported more frequently in patients receiving this drug (5.4% vs 3.4%). There was insufficient information available to determine if these events were associated with hypoglycemia.[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Amaryl (glimepiride)." Hoechst Marion-Roussel Inc, Kansas City, MO.

Not all side effects for Amaryl may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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