Alferon N Side Effects

Generic Name: interferon alfa-n3

Note: This document contains side effect information about interferon alfa-n3. Some of the dosage forms listed on this page may not apply to the brand name Alferon N.

Some side effects of Alferon N may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to interferon alfa-n3: injection solution

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; changes in taste or hearing; chills; diarrhea; fatigue; flu-like symptoms; headache; muscle and joint pain; nausea; pain or other reaction at the site of injection; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking interferon alfa-n3 (the active ingredient contained in Alferon N)

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; bloody diarrhea; chest pain; dark urine or changes in amount of urine; depression; difficulty sleeping; dizziness; drowsiness; intolerance to heat or cold; irregular heartbeat; one-sided weakness (arm, leg); persistent sore throat; poor coordination; pounding in the chest; psychotic or manic behavior; seizures; severe stomach/abdominal pain; suicidal thoughts; tingling hands or feet; unusual bleeding/bruising; unusual increase in thirst; vision changes; vomiting blood; yellowing of the skin or eyes.

For Healthcare Professionals

Applies to interferon alfa-n3: injectable solution

General

Side effects were evaluated in 202 patients with condylomata acuminata receiving interferon alfa-n3 (the active ingredient contained in Alferon N) by intralesional administration and in 31 patients with cancer receiving interferon alfa-n3 by systemic administration.

Most of the systemic side effects reported in patients with condylomata acuminata were mild or moderate. Severe systemic side effects were reported in 18% of patients treated with interferon alfa-n3 and 13% of patients treated with placebo. The severe systemic side effects reported were influenza-like symptoms (most common), back pain, insomnia, and sensitivity to allergens.

The occurrence of side effects in patients with cancer was determined to be unrelated to the intramuscular dose of interferon alfa-n3.

Musculoskeletal

Musculoskeletal side effects have included myalgias (45%), arthralgia (5%), back pain (4%), and muscle cramps (1%). Myalgias (16%; severe: 13%), arthralgia (10%; severe: 3%), and muscle soreness (severe: 3%) have been reported in patients with cancer.

Other

Other side effects have included fever (40%), influenza-like symptoms (including myalgias, fever, and/or headache; 30%), chills (14%), fatigue (14%), malaise (9%), and sweating (2%)., Left groin lymph node swelling, thirst, hot sensation on bottom of feet, heat intolerance, hot flashes, throat tightness, and decrease in concentration have been reported in 1% of patients. Chills (87%; severe: 45%), fever (81%; severe: 55%), anorexia (68%; severe: 45%), malaise (65%; severe: 54%), chest pains (10%; severe: 6%), fatigue (6%; severe: 6%), stiff shoulders (severe: 3%), sweating (severe: 3%), flushed face, edema, shakes/shivers, and cramps have been reported in patients with cancer.

Nervous system

Nervous system side effects have included headache (31%), dizziness (9%), insomnia (2%), vasovagal reaction (2%), tongue hyperesthesia (1%), and tingling of legs/feet (1%). Sleepiness (10%; severe: 3%), headache (10%; severe: 3%), numbness (severe: 3%), confusion (severe: 3%), lightheadedness (severe: 3%), numbness in hands, numbness in fingers, and ringing in ears have been reported in patients with cancer.

Gastrointestinal

Gastrointestinal side effects have included nausea (4%), vomiting (3%), dyspepsia/heartburn (3%), diarrhea (2%), strange taste in mouth (1%), and increased salivation (1%). Nausea (48%; severe: 16%), vomiting (29%; severe: 10%), diarrhea (6%; severe: 3%), sore mouth/stomatitis (6%; severe: 6%), dry mouth, mucositis, constipation, and upset stomach have been reported in patients with cancer.

Hematologic

Hematologic side effects have included decreased white blood cells (11%). Abnormal hemoglobin level (7%), white blood cell count (3%), and platelet count (3%) have been reported in patients with cancer.

Dermatologic

Dermatologic side effects have included generalized pruritus (2%), papular rash on neck (1%), photosensitivity (1%), and herpes labialis (1%).

Psychiatric

Psychiatric side effects have included depression (2%) and nervousness (1%). Depression (severe: 3%) has been reported in patients with cancer.

Respiratory

Respiratory side effects have included nose/sinus drainage (2%), pharyngitis (1%), and nosebleed (1%). Coughing has been reported in patients with cancer.

Local

Local side effects have included application site disorders (such as itching and pain) in 12% of patients treated with interferon alfa-n3 (the active ingredient contained in Alferon N) and 26% of patients treated with placebo. Soreness at injection site (10%) has been reported in patients with cancer.

Ocular

Ocular side effects have included visual disturbances (1%). Blurred vision (6%; severe: 3%) and pain on ocular rotation (severe: 3%) have been reported in patients with cancer.

Genitourinary

Genitourinary side effects have included dysuria (1%).

Immunologic

Immunologic side effects have included swollen lymph nodes (1%).

Cardiovascular

Cardiovascular side effects have included low blood pressure (6%; severe: 6%) in patients with cancer.

Metabolic

Metabolic side effects have included abnormal alkaline phosphatase (8%) in patients with cancer.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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