Alferon N Side Effects
Generic name: interferon alfa-n3
Note: This document contains side effect information about interferon alfa-n3. Some of the dosage forms listed on this page may not apply to the brand name Alferon N.
Some side effects of Alferon N may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to interferon alfa-n3: injectable solution
Get emergency medical help if you have any of these signs of an allergic reaction while taking interferon alfa-n3 (the active ingredient contained in Alferon N) hives; chest tightness, wheezing, feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have flu symptoms such as fever, chills, and body aches.
Less serious side effects of interferon alfa-n3 may include:
headache, tired feeling;
joint or muscle pain, back pain;
mild nausea; or
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to interferon alfa-n3: injectable solution
Side effects were evaluated in 202 patients with condylomata acuminata receiving interferon alfa-n3 (the active ingredient contained in Alferon N) by intralesional administration and in 31 patients with cancer receiving interferon alfa-n3 by systemic administration.
Most of the systemic side effects reported in patients with condylomata acuminata were mild or moderate. Severe systemic side effects were reported in 18% of patients treated with interferon alfa-n3 and 13% of patients treated with placebo. The severe systemic side effects reported were influenza-like symptoms (most common), back pain, insomnia, and sensitivity to allergens.
The occurrence of side effects in patients with cancer was determined to be unrelated to the intramuscular dose of interferon alfa-n3.
Musculoskeletal side effects have included myalgias (45%), arthralgia (5%), back pain (4%), and muscle cramps (1%). Myalgias (16%; severe: 13%), arthralgia (10%; severe: 3%), and muscle soreness (severe: 3%) have been reported in patients with cancer.
Other side effects have included fever (40%), influenza-like symptoms (including myalgias, fever, and/or headache; 30%), chills (14%), fatigue (14%), malaise (9%), and sweating (2%)., Left groin lymph node swelling, thirst, hot sensation on bottom of feet, heat intolerance, hot flashes, throat tightness, and decrease in concentration have been reported in 1% of patients. Chills (87%; severe: 45%), fever (81%; severe: 55%), anorexia (68%; severe: 45%), malaise (65%; severe: 54%), chest pains (10%; severe: 6%), fatigue (6%; severe: 6%), stiff shoulders (severe: 3%), sweating (severe: 3%), flushed face, edema, shakes/shivers, and cramps have been reported in patients with cancer.
Nervous system side effects have included headache (31%), dizziness (9%), insomnia (2%), vasovagal reaction (2%), tongue hyperesthesia (1%), and tingling of legs/feet (1%). Sleepiness (10%; severe: 3%), headache (10%; severe: 3%), numbness (severe: 3%), confusion (severe: 3%), lightheadedness (severe: 3%), numbness in hands, numbness in fingers, and ringing in ears have been reported in patients with cancer.
Gastrointestinal side effects have included nausea (4%), vomiting (3%), dyspepsia/heartburn (3%), diarrhea (2%), strange taste in mouth (1%), and increased salivation (1%). Nausea (48%; severe: 16%), vomiting (29%; severe: 10%), diarrhea (6%; severe: 3%), sore mouth/stomatitis (6%; severe: 6%), dry mouth, mucositis, constipation, and upset stomach have been reported in patients with cancer.
Hematologic side effects have included decreased white blood cells (11%). Abnormal hemoglobin level (7%), white blood cell count (3%), and platelet count (3%) have been reported in patients with cancer.
Dermatologic side effects have included generalized pruritus (2%), papular rash on neck (1%), photosensitivity (1%), and herpes labialis (1%).
Psychiatric side effects have included depression (2%) and nervousness (1%). Depression (severe: 3%) has been reported in patients with cancer.
Respiratory side effects have included nose/sinus drainage (2%), pharyngitis (1%), and nosebleed (1%). Coughing has been reported in patients with cancer.
Local side effects have included application site disorders (such as itching and pain) in 12% of patients treated with interferon alfa-n3 (the active ingredient contained in Alferon N) and 26% of patients treated with placebo. Soreness at injection site (10%) has been reported in patients with cancer.
Ocular side effects have included visual disturbances (1%). Blurred vision (6%; severe: 3%) and pain on ocular rotation (severe: 3%) have been reported in patients with cancer.
Genitourinary side effects have included dysuria (1%).
Immunologic side effects have included swollen lymph nodes (1%).
Cardiovascular side effects have included low blood pressure (6%; severe: 6%) in patients with cancer.
Metabolic side effects have included abnormal alkaline phosphatase (8%) in patients with cancer.
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