Aerospan HFA Side Effects
Generic Name: flunisolide
Note: This page contains information about the side effects of flunisolide. Some of the dosage forms included on this document may not apply to the brand name Aerospan HFA.
Not all side effects for Aerospan HFA may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to flunisolide: inhalation aerosol powder
In addition to its needed effects, some unwanted effects may be caused by flunisolide (the active ingredient contained in Aerospan HFA). In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking flunisolide:More common
- Body aches or pain
- dryness or soreness of the throat
- pain or tenderness around the eyes and cheekbones
- shortness of breath or troubled breathing
- stuffy or runny nose
- tender, swollen glands in the neck
- tightness of the chest or wheezing
- trouble with swallowing
- voice changes
- Bladder pain
- blistering, peeling, or loosening of the skin
- bloating or swelling of the face, arms, hands, lower legs, or feet
- bloody nose
- bloody or cloudy urine
- blurred vision
- chest pain
- cough producing mucus
- difficult, burning, or painful urination
- fast, irregular, pounding, or racing heartbeat or pulse
- frequent urge to urinate
- general feeling of discomfort or illness
- joint or muscle pain
- lower back or side pain
- pounding in the ears
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- red, irritated eyes
- skin rash
- slow heartbeat
- sore mouth or tongue
- sores, ulcers, or white spots in the mouth or on the lips
- tingling of the hands or feet
- unusual tiredness or weakness
- unusual weight gain or loss
- Creamy white, curd-like patches in the mouth or throat
- darkening of the skin
- feeling sad or empty
- loss of appetite
- loss of interest or pleasure
- loss of strength or energy
- muscle weakness
- pain when eating or swallowing
- trouble concentrating
- trouble sleeping
Some of the side effects that can occur with flunisolide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:Less common
- Abdominal or stomach fullness
- acid or sour stomach
- appetite changes
- bad, unusual, or unpleasant (after) taste
- blemishes on the skin
- burning, dry, or itching eyes
- change in taste
- difficulty with moving
- discharge or excessive tearing
- dizziness or lightheadedness
- ear pain
- feeling of constant movement of self or surroundings
- headache, severe and throbbing
- heavy bleeding
- itching of the vagina or genital area
- loss of smell or taste
- muscle aching or cramping
- muscle stiffness
- pain during sexual intercourse
- pain in the neck
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
- sensation of spinning
- skin rash, encrusted, scaly, and oozing
- stomach discomfort, upset, or pain
- swollen joints
- thick, white vaginal discharge with no odor or with a mild odor
- trouble sitting still
- trouble sleeping
- upset stomach
For Healthcare Professionals
Applies to flunisolide: compounding powder, inhalation aerosol, inhalation aerosol with adapter
Flunisolide (the active ingredient contained in Aerospan HFA) has been generally well tolerated and, due to the nature of its administration, has not been inclined to produce the adverse effects generally associated with the systemic use corticosteroids.
Gastrointestinal side effects have included oropharyngeal candidiasis in approximately 3% to 9% of patients treated, as well as nausea and vomiting (25%), diarrhea (10%), and upset stomach (10%). In addition, flunisolide (the active ingredient contained in Aerospan HFA) has produced a bitter taste in most patients.
To reduce the incidence of thrush, patients should be instructed to rinse their mouths following the use of flunisolide. Limited data suggest that the incidence of thrush secondary to inhaled corticosteroids may be lower in patients utilizing a spacer device and good inhalation technique.
Many patients who experience coughing and wheezing may benefit from pretreatment with an inhaled beta-agonist prior to administration of flunisolide (the active ingredient contained in Aerospan HFA)
Respiratory side effects have included dysphonia, sore throat, and cold symptoms. Coughing and wheezing have also been frequently reported, especially in patients whose disease is poorly controlled. Nasal irritation, burning and stinging, congestion, epistaxis, sneezing, and rarely, nasal septal perforations have been reported with intranasal administration. Temporary or permanent loss of the sense of smell and taste have occurred with both oral inhalation and intranasal formulations. Upper respiratory tract infections are also more common in patients receiving flunisolide.
Nervous system side effects have generally been limited to headache, which has occurred in up to 25% of patients. Dizziness, nervousness, shakiness, depression, and insomnia have been reported in less than 10% of patients.
Endocrine side effects have rarely included suppression of the hypothalamic-pituitary-adrenal axis. The risk of adrenal suppression has been less than that associated with systemic corticosteroids and, generally, has been only of concern when using higher than recommended doses.
In 1993, the American Academy of Allergy and Immunology (AAAI) requested the FDA review their decision concerning the relabeling of inhaled corticosteroids with respect to the risk of their use during severe viral infections. The AAAI's request was based on the lack of data linking inhaled corticosteroids to increases in complications of viral infections.
Immunologic side effects have included the danger of infections from immune suppression associated with inhaled corticosteroids. No conclusive evidence is available to support an increase in tuberculosis or viral infections in patients receiving inhaled corticosteroids.
Musculoskeletal side effects have included the potential of reduction in bone density with the long term use of inhaled corticosteroids. This effect may have been dose-related and has been reported with high dosages of orally inhaled beclomethasone and budesonide (>= 800 mcg/day for >= 1 year). Reduced levels of total body calcium have also been demonstrated in patients receiving lower dosages.
Ocular side effects have included occasional reports of capsular cataracts, especially with long-term use. In addition, one epidemiologic study suggested that prolonged use of high-dose inhaled corticosteroids (>= 1500 mcg of flunisolide (the active ingredient contained in Aerospan HFA) may be associated with increased risk of ocular hypertension and open-angle glaucoma.
Dermatologic side effects have included eczema, acne, rash, and urticaria. Easy bruising has also been associated with flunisolide (the active ingredient contained in Aerospan HFA) use in some patients.
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