Adapalene Side Effects

Please note - some side effects for Adapalene may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Adapalene - for the Consumer

Adapalene Cream

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Adapalene Cream:

Temporary burning and stinging; dry skin; feeling of warmth; irritation; itching; peeling; redness; scaling.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering; crusting; excessive redness or peeling; swelling.

Adapalene and Benzoyl Peroxide Gel

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Adapalene and Benzoyl Peroxide Gel:

Dry skin; feeling of warmth; irritation; itching; peeling; redness; scaling; temporary burning and stinging.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering; crusting; excessive redness, peeling, or irritation; swelling.

Adapalene Pads

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Adapalene Pads:

Acne; dry skin; feeling of warmth; irritation; itching; peeling; redness; scaling; sunburn; temporary burning or stinging.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering; crusting; excessive redness or peeling; swelling.

Adapalene Solution

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Adapalene Solution:

Acne; dry skin; feeling of warmth; irritation; itching; peeling; redness; scaling; sunburn; temporary burning or stinging.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering; crusting; excessive redness or peeling; swelling.

Side Effects by Body System

Local

Local side effects have included erythema, scaling, dryness, burning, and pruritus in 30 to 60% of patients. Persistent pruritus and stinging have been reported in up to 24% of patients. Skin irritation, acne flares, sunburn, and skin discoloration have been reported rarely (less than 1%).

Erythema, scaling, dryness, burning, and pruritus usually occur during the first 2 to 4 weeks of therapy and lessen with continued use. Burning and itching immediately after application occurs in approximately 20% to 30% of patients.

All local side effects occurring with adapalene topical appear to be reversible upon discontinuation of therapy.

Dermatologic

Dermatologic side effects have rarely included dermatitis, contact dermatitis, rash and eczema.

Ocular

Ocular side effects have rarely included eyelid edema and conjunctivitis.

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