Adapalene Cream Side Effects
Please note - some side effects for Adapalene Cream may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Adapalene Cream Side Effects - for the Professional
Adapalene Cream
In controlled clinical trials, local cutaneous irritation was monitored in 285 acne patients who used Adapalene Cream once daily for 12 weeks. The frequency and severity of erythema, scaling, dryness, pruritus and burning were assessed during these studies. The incidence of local cutaneous irritation with Adapalene Cream from the controlled clinical studies is provided in the following table:
| None | Mild | Moderate | Severe | |
| Erythema | 52% (148) | 38% (108) | 10% (28) | <1% (1) |
| Scaling | 58% (166) | 35% (100) | 6% (18) | <1% (1) |
| Dryness | 48% (136) | 42% (121) | 9% (26) | <1% (2) |
| Pruritis (persistent) | 74% (211) | 21% (61) | 4% (12) | <1% (1) |
| Burning/Stinging (persistent) | 71% (202) | 24% (69) | 4% (12) | <1% (2) |
Other reported local cutaneous adverse events in patients who used Adapalene Cream once daily included: sunburn (2%), skin discomfort-burning and stinging (1%) and skin irritation (1%). Events occurring in less than 1% of patients treated with Adapalene Cream included: acne flare, dermatitis and contact dermatitis, eyelid edema, conjunctivitis, erythema, pruritus, skin discoloration, rash, and eczema.
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