Adapalene and benzoyl peroxide Side Effects

Please note - some side effects for Adapalene and benzoyl peroxide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects of Adapalene and benzoyl peroxide - for the Consumer

Adapalene and benzoyl peroxide Gel

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Adapalene and benzoyl peroxide Gel:

Dry skin; feeling of warmth; irritation; itching; peeling; redness; scaling; temporary burning and stinging.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering; crusting; excessive redness, peeling, or irritation; swelling.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

Side Effects by Body System - for Healthcare Professionals

Applies to: topical gel

Dermatologic

Dermatologic reactions during a clinical study included erythema, scaling, dryness and stinging/burning. These reactions occurred in 27% to 41% of study participants and were mostly mild to moderate, with only 1% to 3% experiencing severe reactions. Analysis of study data during a 12-week period showed that side effects such as erythema, scaling, dryness, and stinging/burning peaked during the first week of therapy and decreased thereafter.

Dermatologic side effects have included dry skin (7%), contact dermatitis (3%), application site burning (2%), application site irritation (1%), and skin irritation (1%).

General

General side effects reported postmarketing have included eyelid edema, sunburn, blister, pain of skin, pruritus, swelling face, conjunctivitis, skin discoloration, rash, eczema, and allergic contact dermatitis.

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