Acyclovir / hydrocortisone topical Side Effects

Some side effects of acyclovir / hydrocortisone topical may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to acyclovir / hydrocortisone topical: topical application cream

Along with its needed effects, acyclovir / hydrocortisone topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acyclovir / hydrocortisone topical:

Rare
  • Burning, itching, redness, skin rash, swelling, or soreness at the application site
  • change in skin color at the application site
  • dryness or flaking of the skin
  • flushing or redness of the skin
  • unusually warm skin
Incidence not known
  • Blistering, burning, or crusting of the skin
  • itching, scaling, severe redness, soreness, or swelling of the skin

For Healthcare Professionals

Applies to acyclovir / hydrocortisone topical: topical cream

General

During clinical trials, most side effects were local skin reactions and occurred around the application site.

Local

Uncommon (0.1% to 1%): Local skin reactions in application site area (including drying or flaking of skin, burning or tingling after application, erythema, pigmentation changes, application site reaction [including signs/symptoms of inflammation])
Frequency not reported: High and cumulative irritation potential

A high and cumulative irritation potential under occlusive and semiocclusive conditions was reported during a 21-day cumulative irritation trial.

Hypersensitivity

Frequency not reported: Contact allergy, sensitization to hydrocortisone, possible sensitization to drug's base

During a photosafety study, one subject developed a contact allergy to propylene glycol (one of the inactive ingredients of the cream base).

Dermatologic

Frequency not reported: Contact dermatitis

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