Activella Side Effects
Generic name: estradiol / norethindrone
Note: This document contains side effect information about estradiol / norethindrone. Some of the dosage forms listed on this page may not apply to the brand name Activella.
Some side effects of Activella may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to estradiol / norethindrone: tablets
Other dosage forms:
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking estradiol / norethindrone:
Back pain; breast tenderness or pain; headache; mild hair loss; nausea; stomach cramps, bloating, or pain; vaginal spotting or breakthrough bleeding; vomiting; weight changes.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); calf or leg pain, swelling, or tenderness; chest pain; confusion; discharge from the nipples; fainting; irregular heartbeat; lumps in the breast; mental or mood changes (eg, depression, irritability, memory loss); numbness of an arm or leg; one-sided weakness; severe or persistent breast pain; severe or persistent dizziness, headache, or stomach pain; severe, persistent, or recurring abnormal vaginal bleeding; speech changes (eg, slurred speech); sudden severe nausea or vomiting; sudden shortness of breath; sudden unusual weight gain; swelling of hands or feet; unusual vaginal discharge, itching, or odor; vision changes (eg, double vision, sudden vision loss); yellowing of the skin or eyes.
For Healthcare Professionals
Applies to estradiol / norethindrone: oral tablet, transdermal film extended release
Gastrointestinal side effects have included nausea (8% to 11%), abdominal pain (6% to 7%), diarrhea (4% to 5%), flatulence (4% to 5%), and dyspepsia (1% to 5%).
General side effects have included headache (18% to 20%), asthenia (8% to 12%), back pain (9% to 11%), flu syndrome (5% to 9%), pain (4% to 6%), and accidental injury (4% to 5%).
Genitourinary side effects have included breast pain (25% to 31%), dysmenorrhea (20% to 21%), vaginitis (6% to 13%), menstrual disorder (6% to 12%), suspicious Papanicolaou smear (4% to 8%), and leukorrhea (5%). Endometrial thickening (10% to 4%) and vaginal hemorrhage (26% to 12%) have also been reported.
Local side effects have included reactions at the application site (2% to 6%).
Psychiatric side effects have included nervousness (3% to 6%) and depression (3% to 6%).
Respiratory side effects have included rhinitis (7% to 13%), respiratory disorder (7% to 12%), pharyngitis (4% to 10%), and sinusitis (4% to 9%).
More Activella resources
- Activella Concise Consumer Information (Cerner Multum)
- Activella MedFacts Consumer Leaflet (Wolters Kluwer)
- Activella Prescribing Information (FDA)
- Activella Advanced Consumer (Micromedex) - Includes Dosage Information
- CombiPatch patch (bi-weekly) MedFacts Consumer Leaflet (Wolters Kluwer)
- CombiPatch Prescribing Information (FDA)
- Combipatch topical patches Concise Consumer Information (Cerner Multum)
- Combipatch Advanced Consumer (Micromedex) - Includes Dosage Information
- Enablex Monograph (AHFS DI)
- Enalaprilat/Enalapril Maleate Monograph (AHFS DI)
- Mimvey Prescribing Information (FDA)
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