Actidose Plus Sorbitol Side Effects

Generic Name: charcoal / sorbitol

Note: This page contains information about the side effects of charcoal / sorbitol. Some of the dosage forms included on this document may not apply to the brand name Actidose Plus Sorbitol.

Not all side effects for Actidose Plus Sorbitol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to charcoal / sorbitol: suspension

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; temporary darkening of the stool; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking charcoal / sorbitol:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

For Healthcare Professionals

Applies to charcoal / sorbitol: oral suspension

Gastrointestinal

Gastrointestinal side effects have frequently included nausea and vomiting (13% to 30%) and constipation. Bowel obstruction, ileus, chalk-like taste, perforation of the gastrointestinal tract and subsequent charcoal peritoneum, diarrhea, and black colored stools have also been reported.

A young woman developed a surgically acute abdomen following orogastric lavage and charcoal administration. Laparotomy revealed charcoal throughout the peritoneum. Complications included peritonitis, adhesions, abscess formation, persistent peritoneal charcoal deposits, oophorectomy, and small bowel resection.

A case of a charcoal bezoar and small bowel obstruction following administration of 30 to 60 grams of activated charcoal via nasogastric tube every 4 to 6 hours for 5 days has been reported.

In a study of 275 patients, 18 years old or younger, 20.4% (56/275) experienced vomiting within < 1 to 120 minutes (mean of 10 minutes) following enteral administration of 1 g/kg (no more than 50 g) of activated charcoal for acute poison ingestion. The following risk factors for vomiting were identified: nausea, a vomiting occurrence prior to charcoal ingestion, presence of signs or symptoms of poisoning (exclusive of nausea &/or vomiting), age > 12 years, administration by nasogastric or orogastric tube, and ingestion of emetogenic drug or chemical. Charcoal with sorbitol solution did not appear to significantly increase the risk of vomiting.

Bowel obstruction and ileus have occurred with multiple dose administration.

Although charcoal is tasteless, it adheres to the surfaces of the mouth and tongue, producing a chalk-like taste which can be unpalatable.

Ocular

Corneal abrasions may occur if charcoal comes in contact with eyes.

Ocular side effects have included corneal abrasions.

Metabolic

Metabolic side effects result primarily from the sorbitol and have included electrolyte abnormalities, dehydration, and shock.

Respiratory

Bronchiolitis obliterans and empyema have occurred due to charcoal aspiration following emesis.

Accidental administration of charcoal directly into the lungs has resulted in Adult Respiratory Distress Syndrome.

Respiratory side effects have included bronchiolitis obliterans, empyema, and Adult Respiratory Distress Syndrome.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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