Acetaminophen / dextromethorphan / doxylamine / phenylephrine Side Effects
Some side effects of acetaminophen / dextromethorphan / doxylamine / phenylephrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to acetaminophen / dextromethorphan / doxylamine / phenylephrine: liquid
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking acetaminophen / dextromethorphan / doxylamine / phenylephrine:
Dizziness; drowsiness; dry mouth, nose, or throat; headache; nausea; nervousness; trouble sleeping.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine; difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; mental or mood changes; pale stools; seizures; severe nervousness, drowsiness, or trouble sleeping; severe or persistent dizziness, lightheadedness, or headache; severe or persistent stomach pain, nausea, or vomiting; tremor; unusual fatigue; vision changes; yellowing of the skin or eyes.
For Healthcare Professionals
Applies to acetaminophen / dextromethorphan / doxylamine / phenylephrine: oral liquid, oral tablet effervescent
Cardiovascular side effects have included palpitations, arrhythmias, and cardiovascular collapse with hypotension.
Dermatologic side effects associated with acetaminophen includes the risk of rare but potentially fatal serious skin reactions known as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP).
Gastrointestinal side effects have included nausea and vomiting.
Genitourinary side effects have included dysuria.
General side effects have included pallor and weakness.
Hypersensitivity side effects have included rare reports of fixed-drug eruptions.
Nervous system side effects have included marked drowsiness and excitability.
Psychiatric side effects have included hallucinations, fear, and anxiety.
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- Acetaminophen, dextromethorphan, doxylamine, and phenylephrine
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