Abiraterone Side Effects

Not all side effects for abiraterone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to abiraterone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by abiraterone. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking abiraterone:

More common
  • Bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • blurred vision
  • bone fracture
  • chest pain or discomfort
  • convulsions
  • decreased urine
  • difficult, burning, or painful urination
  • dizziness
  • dry mouth
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • feeling of warmth
  • frequent urge to urinate
  • headache
  • increased need to urinate
  • increased thirst
  • increased urge to urinate during the night
  • lightheadedness, dizziness, or fainting
  • loss of appetite
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain or swelling in the arms or legs without any injury
  • passing urine more often
  • pounding in the ears
  • rapid weight gain
  • redness of the face, neck, arms, and occasionally, upper chest
  • shortness of breath
  • slow heartbeat
  • sudden sweating
  • swelling
  • swelling with pits or depressions on the skin
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • waking to urinate at night
Less common
  • Abdominal or stomach pain or tenderness
  • arm, back, or jaw pain
  • chest tightness or heaviness
  • clay colored stools
  • cool, sweaty skin
  • dark urine
  • decreased appetite
  • decreased urine output
  • difficulty with breathing
  • dilated neck veins
  • extreme fatigue
  • fever
  • headache
  • irregular breathing
  • itching skin
  • rash
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • weakness
  • weight gain
  • wheezing
  • yellow eyes or skin
Rare
  • Darkening of the skin
  • diarrhea
  • mental depression

Some of the side effects that can occur with abiraterone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Acid or sour stomach
  • belching
  • body aches or pain
  • chills
  • cough
  • difficulty with moving
  • ear congestion
  • heartburn
  • indigestion
  • joint pain
  • loss of voice
  • muscle cramps or spasms
  • muscle or bone pain
  • muscle stiffness
  • nasal congestion
  • runny nose
  • sneezing
  • sore throat
  • stomach discomfort or upset
  • swelling or stiffness of the joints

For Healthcare Professionals

Applies to abiraterone: oral tablet

General

In general, the most commonly reported side effects have included joint swelling or discomfort, hypokalemia, edema, muscle discomfort, hot flushes, diarrhea, urinary tract infection, cough, hypertension, arrhythmia, urinary frequency, nocturia, dyspepsia, and upper respiratory tract infection. The most common adverse effects which resulted in discontinuation of abiraterone have included increased transaminases (ALT, AST), urosepsis, and heart failure.

Cardiovascular

Cardiovascular side effects have included hypertension, edema, hot flushes, arrhythmias, atrial and ventricular tachycardia, supraventricular tachycardia, atrial flutter, bradycardia, AV block, chest pain or discomfort, angina, left ventricular dysfunction, cardiogenic shock, cardiomegaly, cardiomyopathy, decreased ejection fraction, and heart failure.

Endocrine

Endocrine side effects have included adrenocortical insufficiency.

Gastrointestinal

Gastrointestinal side effects have included diarrhea and dyspepsia.

Genitourinary

Genitourinary side effects have included urinary tract infection, urinary frequency, nocturia, and urosepsis.

Hepatic

Hepatic side effects have included hepatotoxicity, increased AST, increased ALT, and increased bilirubin

Metabolic

Metabolic side effects have included hypokalemia, fluid retention, and low serum phosphate.

Musculoskeletal

Musculoskeletal side effects have included joint swelling or discomfort, muscle discomfort, arthritis, arthralgia, muscle spasms, musculoskeletal pain or discomfort, myalgia and fractures.

Respiratory

Respiratory side effects have included cough and upper respiratory tract infection.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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