Rubraca

Generic name: rucaparib [ roo-KAP-a-rib ]
Drug class: PARP inhibitors

Medically reviewed by Judith Stewart, BPharm. Last updated on Jan 26, 2023.

What is Rubraca?

Rubraca is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Rubraca is used to treat ovarian cancer, fallopian tube cancer, or primary peritoneal cancer (cancer of the membrane lining the organs inside your abdomen). Rubraca is sometimes used for these conditions only if your cancer has a specific genetic marker (an abnormal "BRCA" gene). Your doctor will test you for this gene.

Rubraca is also used to treat prostate cancer with an abnormal BRCA gene. It is given for this condition when the cancer has spread to other parts of the body and surgery or other cancer treatments did not work or have stopped working.

Rubraca was approved for prostate cancer by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed.

Warnings

Rubraca can cause leukemia or serious bone marrow problems. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, blood in your urine or stools, shortness of breath, or signs of infection (fever, feeling weak or tired, weight loss).

Before taking this medicine

Using Rubraca may increase your risk of developing serious bone marrow problems or other types of cancer, such as leukemia. Ask your doctor about your specific risk.

Rucaparib can harm an unborn baby if the mother or the father is using this medicine.

• If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Do not use rucaparib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine.

• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

• Tell your doctor right away if a pregnancy occurs.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

How should I take Rubraca?

Take Rubraca exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Rubraca is usually taken once every 12 hours, with or without food.

If you take Rubraca for prostate cancer, you may also be treated with another medicine called a gonadotropin-releasing hormone, or GnRH. GnRH helps prevent the testicles from producing testosterone.

If you vomit shortly after taking a dose of this medicine, do not take another dose. Wait until your next scheduled dose to take the medicine again, but do not take 2 doses at the same time.

You may need frequent medical tests and your cancer treatments may be delayed based on the results.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Men should not donate sperm while taking Rubraca and for at least 3 months after the last dose.

Rucaparib could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Rubraca side effects

Get emergency medical help if you have signs of an allergic reaction to Rubraca: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• blood in your urine; or

• low blood cell counts - fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common Rubraca side effects may include:

• low blood cell counts;

• shortness of breath;

• upset stomach, loss of appetite;

• nausea, vomiting, diarrhea, constipation;

• changes in your sense of taste;

• dizziness, feeling weak or tired;

• increased sensitivity to light;

• rash; or

• abnormal liver and kidney function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Rubraca?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with rucaparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Frequently asked questions

• What type of cancer is Rubraca used to treat?

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Rubraca only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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