Zolpidem Pregnancy and Breastfeeding Warnings
Zolpidem Pregnancy Warnings
According to one case report, zolpidem apparently crosses the placenta. In this report, a sample of cord blood at delivery revealed zolpidem (41 ng/mL) after an unknown amount was ingested by the mother for an unknown duration, possibly throughout pregnancy. The neonate did not exhibit withdrawal symptoms throughout the 48 hour observation period. Postmarketing cases of severe neonatal respiratory depression have been reported when zolpidem was used at the end of pregnancy, especially when taken with other CNS depressants.
Zolpidem has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of incomplete ossification and increased postimplantation fetal loss at doses greater than seven times the maximum recommended human dose or higher; however, teratogenicity was not observed at any dose level. There are no controlled data in human pregnancy. In one case report, zolpidem was found in cord blood at delivery. Zolpidem is only recommended for use during pregnancy when benefit outweighs risk.
Zolpidem Breastfeeding Warnings
Zolpidem is excreted into human milk. Animal data suggest a low risk of teratogenic effects. Adverse effects in nursing infants have not been reported. Zolpidem is considered probably compatible with breast-feeding by Briggs et al.
- Zolpidem use while Breastfeeding (in more detail)
- Zolpidem Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
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