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Tocilizumab Pregnancy and Breastfeeding Warnings

Tocilizumab is also known as: Actemra

Tocilizumab Pregnancy Warnings

Tocilizumab has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of an increase in the incidence of abortion/embryo-fetal death. There are no controlled data in human pregnancy. Tocilizumab should only be given during pregnancy when benefits outweigh risks.

To monitor the outcomes of pregnant women exposed to tocilizumab, a pregnancy registry has been established. Physicians are encouraged to register patients and pregnant women are encouraged to register themselves by calling 1-877-311-8972.

Tocilizumab Breastfeeding Warnings

There are no data on the excretion of tocilizumab into human milk. Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants from tocilizumab, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

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