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Sufentanil Pregnancy and Breastfeeding Warnings

Sufentanil is also known as: Sufenta

Sufentanil Pregnancy Warnings

Sufentanil has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of embryocidal effects. There are no controlled data in human pregnancy. Sufentanil is only recommended for use during pregnancy when benefit outweighs risk.

Embryocidal effects observed in rats and rabbits when administered 2.5 times the upper human intravenous dose for a period of 10 to more than 30 days were most likely due to maternal toxicity.

See references

Sufentanil Breastfeeding Warnings

There are no data on the excretion of sufentanil into human milk. However, because analogs of fentanyl are excreted into human milk, the manufacturer recommends that caution be used when administering sufentanil to nursing women.

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References for pregnancy information

  1. Cohen SE, Tan S, White PF "Sufentanil analgesia following cesarean section: epidural versus intravenous administration." Anesthesiology 68 (1988): 129-34
  2. Satterlee GB, Skora IA "Criteria for use of fentanyl citrate, sufentanil citrate, and alfentanil hydrochloride." Clin Pharm 10 (1991): 635-7
  3. "Product Information. Sufenta (sufentanil)." Janssen Pharmaceutica, Titusville, NJ.
  4. Phillips GH "Epidural sufentanil/bupivacaine combinations for analgesia during labor: effect of varying sufentanil doses." Anesthesiology 67 (1987): 835-8
  5. Grieco WM, Norris MC, Leighton BL, Arkoosh VA, Huffnagle HJ, Honet JE, Costello D "Intrathecal sufentanil labor analgesia - the effects of adding morphine or epinephrine." Anesth Analg 77 (1993): 1149-54
  6. Clotz MA, Nahata MC "Clinical uses of fentanyl, sufentanil, and alfentanil." Clin Pharm 10 (1991): 581-93
  7. Vertommen JD, Lemmens E, Van Aken H "Comparison of the addition of three different doses of sufentanil to 0.125% bupivacaine given epidurally during labour." Anaesthesia 49 (1994): 678-81
  8. Steinberg RB, Dunn SM, Dixon DE, Rehm KL, Pastides H, Hu X "Comparison of sufentanil, bupivacaine, and their combination for epidural analgesia in obstetrics." Reg Anesth 17 (1992): 131-8
  9. Honet JE, Arkoosh VA, Norris MC, Huffnagle HJ, Silverman NS, Leighton BL "Comparison among intrathecal fentanyl, meperidine, and sufentanil for labor analgesia." Anesth Analg 75 (1992): 734-9

References for breastfeeding information

  1. "Product Information. Sufenta (sufentanil)." Janssen Pharmaceutica, Titusville, NJ.

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