Ruxolitinib Pregnancy and Breastfeeding Warnings

Ruxolitinib is also known as: Jakafi

Ruxolitinib Pregnancy Warnings

In animal studies, treatment with ruxolitinib resulted in an increase in late resorptions and reduced fetal weights at maternally toxic doses. There are no adequate and well controlled studies of ruxolitinib in pregnant women. Ruxolitinib should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

FDA pregnancy category: C Benefit should outweigh risk.

Ruxolitinib Breastfeeding Warnings

A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: Unknown Excreted into animal milk: Yes The effects in the nursing infant are unknown.

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