Pyridostigmine Pregnancy and Breast Feeding Warnings

Pyridostigmine is also known as: Mestinon, Mestinon Timespan, Regonol

Overview

If you become pregnant while taking Pyridostigmine Controlled-Release Tablets, discuss with your doctor the benefits and risks of using Pyridostigmine Controlled-Release Tablets during pregnancy. Pyridostigmine Controlled-Release Tablets is excreted in breast milk. If you are or will be breast-feeding while you are using Pyridostigmine Controlled-Release Tablets, check with your doctor or pharmacist to discuss the risks to your baby.

Pyridostigmine Pregnancy Warnings

Pyridostigmine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancy. At normal doses, pyridostigmine is not expected to significantly cross the placenta. One case of microcephaly has been reported; however, causality was unclear (disease or drug etiology). Pyridostigmine in large doses reportedly crosses the placenta and reduces fetal plasma cholinesterase activity. Parenteral anticholinesterases have been associated with premature labor when administered near term. Pyridostigmine is only recommended for use during pregnancy when benefit outweighs risk.

Pyridostigmine Lactation Warnings

Pyridostigmine is excreted into human milk. Conclusions from limited data (2 patients) have estimated that infants would ingest less than 0.1% of the maternal dose. Adverse effects in the infant are unlikely. Pyridostigmine is considered compatible with breast-feeding by the American Academy of Pediatrics.

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