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Perphenazine Pregnancy and Breastfeeding Warnings

Perphenazine is also known as: Trilafon

Overview

It is not known if Perphenazine can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Perphenazine while you are pregnant. Perphenazine is found in breast milk. If you are or will be breast-feeding while you use Perphenazine, check with your doctor. Discuss any possible risks to your baby

Perphenazine Pregnancy Warnings

Hyperreflexia has been reported in the newborn when a phenothiazine was used during pregnancy.

Perphenazine has not been formally assigned to a pregnancy category. Animal studies have not been reported. There are no controlled data in human pregnancy. Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery. There have been reports of agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress and feeding disorder in these neonates. These complications have varied in severity; while in some cases symptoms have been self-limited, in other cases neonates have required intensive care unit support and prolonged hospitalization. Perphenazine should only be given during pregnancy when benefits outweigh risks.

Perphenazine Breastfeeding Warnings

Perphenazine is excreted into human milk. The ratio between the concentration found in breast milk and the serum is approximately one. The dose passed on to the child in the breast milk was approximately 0.1% of that given to the mother. In one case, after 3.5 months, the child was reported to have thrived normally and no signs of drug-induced symptoms were reported.

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