Ofloxacin otic Pregnancy and Breastfeeding Warnings

Ofloxacin otic is also known as: Floxin Otic

Ofloxacin otic Pregnancy Warnings

Ofloxacin otic has been assigned to pregnancy category C by the FDA. Animal studies using high systemic doses have revealed evidence of fetotoxicity and teratogenicity. There are no controlled data in human pregnancies. Cartilage damage and arthropathy are reported in immature animals giving rise to concern over effects on bone formation in the developing fetus. Ofloxacin otic is only recommended for use during pregnancy when benefit outweighs risk.

Ofloxacin otic Breastfeeding Warnings

There are no data on the excretion of ofloxacin otic into human milk. Ofloxacin achieves low plasma levels after otic administration. Oral ofloxacin is excreted into milk at concentrations similar to plasma. Quinolone-induced cartilage erosion and arthropathies that have been observed in juvenile animals render some concern over its possible toxic effects on the developing joints of nursing infants. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue the drug or to discontinue nursing, taking into account the importance of the drug to the mother.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web3)