Niacin Pregnancy and Breastfeeding Warnings

Niacin is also known as: B-3-50, B3-500-Gr, Niacin SR, Niacor, Niacor B3, Niaspan, Nico-400, Nicobid Tempules, Nicolar, Nicotinex, Nicotinic Acid, Slo-Niacin

Niacin Pregnancy Warnings

Niacin has been assigned to pregnancy category C by the FDA when given in doses above the recommended daily allowance (RDA). There are no data from animal reproductive studies or controlled human pregnancy studies. The manufacturers of timed-release niacin do not recommend the use of this form of the drug for pregnant women. The manufacturer recommends that niacin be discontinued in women receiving the drug for primary hypercholesterolemia. If used for hypertriglyceridemia, niacin should be given during pregnancy when there are no alternatives and benefit outweighs risk.

Niacin is converted to niacinamide in vivo. Niacinamide is actively transported across the human placenta such that fetal blood levels of niacinamide are greater than corresponding maternal blood levels. There are no reports of adverse effects of niacin or niacinamide on the human fetus.

Niacin Breastfeeding Warnings

In one study of lactating women who were taking 2 to 60 mg of niacin per day, the average milk concentration ranged from 1.17 to 2.75 mcg/mL, and was directly proportional to dietary intake. The recommended daily allowance (RDA) for niacinamide during lactation is 18 to 20 mg. Dietary supplementation is only necessary in cases of poor nutritional intake.

It is not known whether or not niacin is excreted into human milk. Some studies indicate that it may be excreted into milk in small amounts. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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