Skip to Content

Nabumetone Pregnancy and Breastfeeding Warnings

Nabumetone is also known as: Relafen

Nabumetone Pregnancy Warnings

Nabumetone has been assigned to pregnancy category C by the FDA. While animal studies failed to reveal evidence of teratogenicity, evidence of post-implantation loss has been observed in rats following oral doses which produce 6-methoxy-2-naphthylacetic acid levels similar to those obtained in humans at the maximum daily dose. There are no controlled data in human pregnancy. Use late in pregnancy may result in premature closure of the ductus arteriosus and prolong labor and delivery. It should be avoided near term. Nabumetone is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

See references

Nabumetone Breastfeeding Warnings

There are no data on the excretion of nabumetone or its metabolites into human milk. The active metabolite, 6-methoxy-2-naphthylacetic acid (6MNA), is excreted in the milk of lactating rats. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. Koren G, Pastuszak A, Ito S "Drugs in pregnancy." N Engl J Med 338 (1998): 1128-37
  2. "Product Information. Relafen (nabumetone)." SmithKline Beecham, Philadelphia, PA.

References for breastfeeding information

  1. "Product Information. Relafen (nabumetone)." SmithKline Beecham, Philadelphia, PA.

See Also...

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.