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Nabumetone Pregnancy and Breastfeeding Warnings

Nabumetone is also known as: Relafen

Nabumetone Pregnancy Warnings

Nabumetone has been assigned to pregnancy category C by the FDA. While animal studies failed to reveal evidence of teratogenicity, evidence of post-implantation loss has been observed in rats following oral doses which produce 6-methoxy-2-naphthylacetic acid levels similar to those obtained in humans at the maximum daily dose. There are no controlled data in human pregnancy. Use late in pregnancy may result in premature closure of the ductus arteriosus and prolong labor and delivery. It should be avoided near term. Nabumetone is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

Nabumetone Breastfeeding Warnings

There are no data on the excretion of nabumetone or its metabolites into human milk. The active metabolite, 6-methoxy-2-naphthylacetic acid (6MNA), is excreted in the milk of lactating rats. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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