Minoxidil topical Pregnancy and Breastfeeding Warnings
Minoxidil topical Pregnancy Warnings
Minoxidil topical has been assigned to pregnancy category C by the FDA. Animal studies using oral minoxidil have failed to reveal evidence of teratogenicity, but reduced conception rates and an increased incidence of fetal absorption have been observed in rabbits given 5 times the usual human oral dose. Minoxidil topical should not be administered to pregnant women.
Only four cases of exposure to oral minoxidil in human pregnancy have been reported. In two of these four cases, minoxidil was associated with congenital abnormalities, but the presence of severe hypertension and the use of other drugs, including an ACE inhibitor in one case, make implication of minoxidil as a teratogen or as the sole teratogen difficult. Hypertrichosis was markedly evident in one malformed infant and as the sole abnormality in the other. One infant, whose mother was taking oral minoxidil throughout gestation, showed no adverse effects.
Minoxidil topical Breastfeeding Warnings
Limited data from a single study of a woman who was taking oral minoxidil 7.5 mg daily reveals a maximum milk to maternal plasma concentration ratio of 1:3 at one hour after dosing. Minoxidil was also detected in the breast milk of a woman taking minoxidil orally 5 mg twice a day.
Minoxidil is excreted into breast milk. Because of the potential for adverse effects in nursing infants, minoxidil topical should not be used by nursing women.
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