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Meclofenamate Pregnancy and Breastfeeding Warnings

Meclofenamate is also known as: Meclomen

Meclofenamate Pregnancy Warnings

Meclofenamate has not been formally assigned to a pregnancy category by the FDA; however, other nonsteroidal anti-inflammatory drugs (NSAIDs) have been assigned to FDA pregnancy category C prior to 30 weeks gestation and pregnancy category D at greater than or equal to 30 weeks gestation. Fetotoxicity, minor skeletal malformations (such as supernumerary ribs), and delayed ossification in rodent reproduction trials have been reported, but no major teratogenicity. Prolonged gestation and interference with parturition and with normal development of young before weaning have also been reported. Use of NSAIDs at greater than or equal to 30 weeks gestation may cause premature closure of the ductus arteriosus and prolong labor and delivery. There are no controlled data in human pregnancy. The manufacturer does not recommend meclofenamate for use during pregnancy.

Meclofenamate Breastfeeding Warnings

Trace amounts of meclofenamic acid are excreted in human milk. Because of the possible adverse effects of prostaglandin inhibiting drugs on neonates, a decision should be made to discontinue nursing prior to initiation of the drug.

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