Lapatinib Pregnancy and Breast Feeding Warnings

Lapatinib is also known as: Tykerb

Overview

Lapatinib may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lapatinib while you are pregnant. It is not known if Lapatinib is found in breast milk. Do not breast-feed while taking Lapatinib .

Lapatinib Pregnancy Warnings

Lapatinib has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of minor anomalies (left-sided umbilical artery, cervical rib, and precocious ossification) and an increased death rate. Maternal (animal) toxicity was associated with decreased fetal body weights and minor skeletal variations. There are no controlled data in human pregnancy. Lapatinib should only be given during pregnancy when there are no alternatives and benefit outweighs risk. Because lapatinib can cause fetal harm when administered to a pregnant woman, women should be advised not to become pregnant when taking lapatinib.

Lapatinib Lactation Warnings

There are no data on the excretion of lapatinib into human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from lapatinib, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

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