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Kanamycin Pregnancy and Breastfeeding Warnings

Kanamycin is also known as: Kantrex

Kanamycin Pregnancy Warnings

Kanamycin has been assigned to pregnancy category D by the FDA. Aminoglycosides cross the placenta. Animal studies have failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. There are reports of fetal eighth cranial nerve toxicity and hearing loss after prolonged in utero exposure to kanamycin. If kanamycin is administered to a pregnant woman or a woman who becomes pregnant during therapy, she should be advised of the potential risk to the fetus. Kanamycin is only recommended for use during pregnancy when benefit outweighs risk.

Kanamycin Breastfeeding Warnings

Kanamycin is excreted into breast milk in small amounts (milk:plasma ratios of 0.05 to 0.4). Peak milk concentrations of 18.4 mcg/mL have been reported after administration of 1 g intramuscularly. The manufacturer recommends that because of the potential for serious adverse effects in nursing infants, a decision should be made to discontinue nursing or discontinue kanamycin, taking into account the importance of the drug to the mother. Kanamycin is considered compatible with breast-feeding by the American Academy of Pediatrics.

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